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APOBEC1 complementation factor

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity).

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APOBEC1 complementation factor

Also known as APOBEC1 complementation factor (APOBEC1-stimulating protein).
ACF: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; RNA processing; RNA-binding

Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding; RNA binding; single-stranded RNA binding

Biological Process: cytidine to uridine editing; mRNA modification; protein stabilization

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