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Cyclic AMP-Dependent Transcription Factor ATF-6 Beta (ATF6B) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1325547

This protein is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear… More details

$1595 / 0.5 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B), Recombinant Protein
Full Product Name
Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B), partial
Product Gene Name
ATF6B recombinant protein
Product Synonym Gene Name
ATF6B
Sequence
AELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,412 Da
Sequence Positions
2-396
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
600984
3D Structure
ModBase 3D Structure for Q99941
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ATF6B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATF6B purchase

MBS1325547 is a recombinant protein targeting ATF6B. Also known as Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ATF6B. It may not necessarily be applicable to this product.

NCBI GI #
209954788
NCBI GeneID
1388
NCBI Accession #
NP_001129625.1
UniProt Primary Accession #
Q99941
UniProt Secondary Accession #
Q13269; Q14343; Q14345; Q5SSW7; Q99635; Q99637; Q9H3V9; Q9H3W1; Q9NPL0; B0UYX6
UniProt Related Accession #
Q99941
GenBank Nucleotide #
NM_001136153.1
NCBI Official Full Name
cyclic AMP-dependent transcription factor ATF-6 beta isoform b
NCBI Official Synonym Full Names
activating transcription factor 6 beta
NCBI Official Symbol
ATF6B
NCBI Official Synonym Symbols
G13; CREBL1; CREB-RP
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-6 beta
UniProt Synonym Protein Names
Activating transcription factor 6 beta; ATF6-beta
Protein Family
Cyclic AMP-dependent transcription factor
UniProt Gene Name
ATF6B
UniProt Synonym Gene Names
CREBL1; G13; cAMP-dependent transcription factor ATF-6 beta; ATF6-beta; Creb-rp
NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-6 beta

NCBI Summary for ATF6B

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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UniProt Comments for ATF6B

Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN9CCAC[GA]-3') when NF-Y is bound to ERSE.

Research Articles on ATF6B

1. ATF4 and ATF6beta act synergistically in the negative regulation of placental growth factor mRNA expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ATF6B recombinant protein

 Reference Product  PubMed Publications
 ATF6 recombinant protein  >3 publications with ATF6B and ATF6

Pathways associated with ATF6B recombinant protein

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
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 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram

Diseases associated with ATF6B recombinant protein

 Disease Name  Pubmed Publications
 Cognition Disorders Antibodies  >1 publications with ATF6B and Cognition Disorders
 Brain Diseases Antibodies  >1 publications with ATF6B and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with ATF6B and Nervous System Diseases

Organs/Tissues associated with ATF6B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with ATF6B and Heart
 Prostate Antibodies  >1 publications with ATF6B and Prostate
 Lung Antibodies  >1 publications with ATF6B and Lung
 Brain Antibodies  >1 publications with ATF6B and Brain
 Thyroid Antibodies  >1 publications with ATF6B and Thyroid
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