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Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 (LILRA3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1350606

MBS1350606 is a recombinant protein targeting LILRA3. Also known as Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1160 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3), Recombinant Protein
Full Product Name
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)
Product Gene Name
LILRA3 recombinant protein
Product Synonym Gene Name
LILRA3
Sequence
GPLPKPTLWA EPGSVITQGS PVTLRCQGSL ETQEYHLYRE KKTALWITRI PQELVKKGQF PILSITWEHA GRYCCIYGSH TAGLSESSDP LELVVTGAYS KPTLSALPSP VVTSGGNVTI QCDSQVAFDG FILCKEGEDE HPQCLNSHSH ARGSSRAIFS VGPVSPSRRW SYRCYGYDSR APYVWSLPSD LLGLLVPGVS KKPSLSVQPG PVVAPGEKLT FQCGSDAGYD RFVLYKEWGR DFLQRPGRQP QAGLSQANFT LGPVSRSYGG QYTCSGAYNL SSEWSAPSDP LDILITGQIR ARPFLSVRPG PTVASGENVT LLCQSQGGMH TFLLTKEGAA DSPLRLKSKR QSHKYQAEFP MSPVTSAHAG TYRCYGSLSS NPYLLTHPSD PLELVVSGAA ETLSPPQNKS DSKAGE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
49,187 Da
Sequence Positions
24-439, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
604818
3D Structure
ModBase 3D Structure for Q8N6C8
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LILRA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LILRA3. It may not necessarily be applicable to this product.

NCBI GI #
289547633
NCBI GeneID
11026
NCBI Accession #
NP_001166125.1
UniProt Primary Accession #
Q8N6C8
UniProt Secondary Accession #
O15469; O15470; O75016; Q8N151; Q8N154; Q8NHJ1; Q8NHJ2; Q8NHJ3; Q8NHJ4; J3KPM2
UniProt Related Accession #
Q8N6C8
GenBank Nucleotide #
NM_001172654.2
NCBI Official Full Name
leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2
NCBI Official Synonym Full Names
leukocyte immunoglobulin like receptor A3
NCBI Official Symbol
LILRA3
NCBI Official Synonym Symbols
HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
UniProt Protein Name
Leukocyte immunoglobulin-like receptor subfamily A member 3
UniProt Synonym Protein Names
CD85 antigen-like family member E; Immunoglobulin-like transcript 6; ILT-6; Leukocyte immunoglobulin-like receptor 4; LIR-4; Monocyte inhibitory receptor HM43/HM31; CD_antigen: CD85e
Protein Family
Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name
LILRA3
UniProt Synonym Gene Names
ILT6; LIR4; ILT-6; LIR-4
NCBI Protein Information
leukocyte immunoglobulin-like receptor subfamily A member 3

NCBI Summary for LILRA3

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
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UniProt Comments for LILRA3

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Research Articles on LILRA3

1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LILRA3 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with LILRA3 recombinant protein

 Disease Name  Pubmed Publications
 Arthritis Antibodies  >9 publications with LILRA3 and Arthritis
 Arthritis, Rheumatoid Antibodies  >7 publications with LILRA3 and Arthritis, Rheumatoid
 Inflammation Antibodies  >7 publications with LILRA3 and Inflammation
 Necrosis Antibodies  >3 publications with LILRA3 and Necrosis
 Intestinal Diseases Antibodies  >1 publications with LILRA3 and Intestinal Diseases
 Psoriasis Antibodies  >1 publications with LILRA3 and Psoriasis

Organs/Tissues associated with LILRA3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with LILRA3 and Blood
 Lung Antibodies  >1 publications with LILRA3 and Lung
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