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Protein Tyrosine Phosphatase Type IVA 2 (PTP4A2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1353687

This protein belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain… More details

$820 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein tyrosine phosphatase type IVA 2 (PTP4A2), Recombinant Protein
Full Product Name
Recombinant Human Protein tyrosine phosphatase type IVA 2 (PTP4A2)
Product Gene Name
PTP4A2 recombinant protein
Product Synonym Gene Name
PTP4A2
Sequence
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHC
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
16,367 Da
Sequence Positions
1-164, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601584
3D Structure
ModBase 3D Structure for Q12974
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PTP4A2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTP4A2 purchase

MBS1353687 is a recombinant protein targeting PTP4A2. Also known as Recombinant Human Protein tyrosine phosphatase type IVA 2 (PTP4A2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PTP4A2. It may not necessarily be applicable to this product.

NCBI GI #
304361762
NCBI GeneID
8073
NCBI Accession #
NP_001182029.1
UniProt Primary Accession #
Q12974
UniProt Secondary Accession #
O00649; Q15197; Q15259; Q15260; Q15261; A8K9I8; B4DM39; D3DPP0; E9PGJ6; R4GN50
UniProt Related Accession #
Q12974
GenBank Nucleotide #
NM_001195100.1
NCBI Official Full Name
protein tyrosine phosphatase type IVA 2 isoform 3
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 2
NCBI Official Symbol
PTP4A2
NCBI Official Synonym Symbols
HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
UniProt Protein Name
Protein tyrosine phosphatase type IVA 2
UniProt Synonym Protein Names
HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2
Protein Family
Protein tyrosine phosphatase
UniProt Gene Name
PTP4A2
UniProt Synonym Gene Names
PRL2; PTPCAAX2; PRL-2
NCBI Protein Information
protein tyrosine phosphatase type IVA 2

NCBI Summary for PTP4A2

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
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UniProt Comments for PTP4A2

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Research Articles on PTP4A2

1. Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PTP4A2 recombinant protein

 Reference Product  PubMed Publications
 PTP4A1 recombinant protein  >18 publications with PTP4A2 and PTP4A1
 CDKN3 recombinant protein  >2 publications with PTP4A2 and CDKN3
 CDKN1A recombinant protein  >2 publications with PTP4A2 and CDKN1A
 DUSP23 recombinant protein  >1 publications with PTP4A2 and DUSP23

Pathways associated with PTP4A2 recombinant protein

 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By PRL Pathway antibodies  Signaling Events Mediated By PRL Pathway Diagram

Diseases associated with PTP4A2 recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >9 publications with PTP4A2 and Carcinoma
 Liver Neoplasms Antibodies  >9 publications with PTP4A2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >5 publications with PTP4A2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >5 publications with PTP4A2 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >3 publications with PTP4A2 and Colonic Neoplasms
 Liver Diseases Antibodies  >3 publications with PTP4A2 and Liver Diseases
 Lung Neoplasms Antibodies  >2 publications with PTP4A2 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with PTP4A2 and Cell Transformation, Neoplastic
 Fetal Growth Retardation Antibodies  >1 publications with PTP4A2 and Fetal Growth Retardation
 Mammary Neoplasms, Animal Antibodies  >1 publications with PTP4A2 and Mammary Neoplasms, Animal

Organs/Tissues associated with PTP4A2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >19 publications with PTP4A2 and Liver
 Lymph Antibodies  >3 publications with PTP4A2 and Lymph
 Muscle Antibodies  >3 publications with PTP4A2 and Muscle
 Lymph Node Antibodies  >3 publications with PTP4A2 and Lymph Node
 Lung Antibodies  >3 publications with PTP4A2 and Lung
 Intestine Antibodies  >2 publications with PTP4A2 and Intestine
 Testis Antibodies  >2 publications with PTP4A2 and Testis
 Bone Marrow Antibodies  >2 publications with PTP4A2 and Bone Marrow
 Ovary Antibodies  >2 publications with PTP4A2 and Ovary
 Heart Antibodies  >2 publications with PTP4A2 and Heart
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