Mouse PAI-1 Native Protein – Cat# MBS135975

PAI-1 Mouse Native Protein

Name: PAI-1 Native Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS135975
Price: 690 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135975

This organ is an ideal negative control for western blotting, immunoprecipitation, immunohistochemistry and other experiments involving PAI-1. Collected and flash frozen from homozygous PAI-1 knockout mice of strain B6.129S2-Serpine1 tm1Mlg /J. Each mouse… More details

$690 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAI-1, Native Protein

Full Product Name

Mouse PAI-1 genetically deficient lung

Product Gene Name

PAI-1 native protein

Host

Mouse

Form/Format

Frozen tissue

Preparation and Storage

Recommended Storage: At -70 degree C
Minimum Shelf Life: 3 years from delivery
Shipping Condition: Dry ice

Molecular Weight

45,170 Da

3D Structure

ModBase 3D Structure for P22777

Source Info

PAI-1 knockout mouse

Product Categories/Family for PAI-1 native protein

PAI-1 KNOCKOUT MOUSE PLASMA AND ORGANS

Other Notes

Small volumes of PAI-1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAI-1 purchase

MBS135975 is a native protein targeting PAI-1. Also known as Mouse PAI-1 genetically deficient lung. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PAI-1. It may not necessarily be applicable to this product.

NCBI GI #

129577

NCBI GeneID

18787

NCBI Accession #

P22777.1

UniProt Primary Accession #

P22777

UniProt Related Accession #

P22777

NCBI Official Full Name

Plasminogen activator inhibitor 1

NCBI Official Synonym Full Names

serine (or cysteine) peptidase inhibitor, clade E, member 1

NCBI Official Symbol

Serpine1

NCBI Official Synonym Symbols

PAI1; PAI-1; Planh1

UniProt Protein Name

Plasminogen activator inhibitor 1

UniProt Synonym Protein Names

Endothelial plasminogen activator inhibitor; Serpin E1

Protein Family

Plasminogen activator inhibitor

UniProt Gene Name

Serpine1

UniProt Synonym Gene Names

Mr1; Pai1; Planh1; PAI; PAI-1

UniProt Entry Name

PAI1_MOUSE

NCBI Protein Information

plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activator inhibitor, type I; endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)

UniProt Comments for PAI-1

SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; protease inhibitor activity; receptor binding

Biological Process: positive regulation of keratinocyte migration; positive regulation of blood coagulation; wound healing; negative regulation of peptidase activity; positive regulation of coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; regulation of angiogenesis; positive regulation of receptor-mediated endocytosis; regulation of cell proliferation; positive regulation of interleukin-8 production; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; negative regulation of fibrinolysis; regulation of receptor activity; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; female gonad development; positive regulation of inflammatory response

Research Articles on PAI-1

1. Data indicate that plasminogen activator inhibitor type-1 (PAI-1)-mediated migration of CpG-ODN-stimulated macrophages is low-density lipoprotein receptor-related protein 1 (LRP1)-independent.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PAI-1 native protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Blood Clotting Cascade Pathway antibodies	Blood Clotting Cascade Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Chagas Disease (American Trypanosomiasis) Pathway antibodies	Chagas Disease (American Trypanosomiasis) Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Dissolution Of Fibrin Clot Pathway antibodies	Dissolution Of Fibrin Clot Pathway Diagram
ECM Proteoglycans Pathway antibodies	ECM Proteoglycans Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Organs/Tissues associated with PAI-1 native protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>586 publications with PAI-1 and Connective Tissue
Lung Antibodies	>581 publications with PAI-1 and Lung
Embryonic Tissue Antibodies	>330 publications with PAI-1 and Embryonic Tissue
Eye Antibodies	>109 publications with PAI-1 and Eye
Bone Marrow Antibodies	>107 publications with PAI-1 and Bone Marrow
Joint Antibodies	>98 publications with PAI-1 and Joint
Spleen Antibodies	>26 publications with PAI-1 and Spleen
Testis Antibodies	>22 publications with PAI-1 and Testis
Mammary Gland Antibodies	>19 publications with PAI-1 and Mammary Gland
Thymus Antibodies	>4 publications with PAI-1 and Thymus