Kininogen (KNG1) ELISA Kit

Name: KNG1 ELISA Kit; Kininogen; MyBioSource
Brand: MyBioSource
SKU: MBS136014
Price: 660 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS136014

High molecular weight kininogen (HK, aka Fitzgerald Factor) is the single chain 626 amino acid 120kDa glycoprotein precursor of the vasoactive peptide bradykinin. Kininogen is an important cofactor for the activation of zymogens prekallikrein, Factor XII, and… More details

$660 / 1 Kit +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Kininogen (KNG1), ELISA Kit

Full Product Name

Human Kininogen total antigen assay ELISA kit

Product Gene Name

KNG1 elisa kit

Preparation and Storage

Store at 4 degree C

Molecular Weight

43,822 Da

OMIM

228960

Product Categories/Family for KNG1 elisa kit

CLOTTING FACTOR ELISA Kits; Human Kininogen ELISA Kits; Human Kits

Other Notes

Small volumes of KNG1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KNG1 purchase

MBS136014 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Kininogen (KNG1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KNG1. The ELISA analytical biochemical technique of the MBS136014 kit is based on KNG1 antibody-KNG1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KNG1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KNG1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for KNG1. It may not necessarily be applicable to this product.

NCBI GI #

386853

NCBI GeneID

3827

NCBI Accession #

AAB59551.1

UniProt Secondary Accession #

P01043; Q53EQ0; Q6PAU9; Q7M4P1; A8K474; B2RCR2; C9JEX1

UniProt Related Accession #

P01042

NCBI Official Full Name

kininogen

NCBI Official Synonym Full Names

kininogen 1

NCBI Official Symbol

KNG1

NCBI Official Synonym Symbols

BK; BDK; KNG

UniProt Protein Name

Kininogen-1

UniProt Synonym Protein Names

Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK

Protein Family

Kininogen

UniProt Gene Name

KNG1

UniProt Synonym Gene Names

BDK; KNG; HMWK

UniProt Entry Name

KNG1_HUMAN

NCBI Protein Information

kininogen-1

UniProt Comments for KNG1

KNG1: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency). HMWK deficiency is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Contractile; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: cysteine protease inhibitor activity; protein binding; receptor binding

Biological Process: blood coagulation, intrinsic pathway; elevation of cytosolic calcium ion concentration; negative regulation of blood coagulation; negative regulation of cell adhesion; negative regulation of proteolysis; platelet degranulation

Disease: High Molecular Weight Kininogen Deficiency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with KNG1 elisa kit

Products by Pathway	Pathway Diagram
ACE Inhibitor Pathway antibodies	ACE Inhibitor Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with KNG1 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>13 publications with KNG1 and Cardiovascular Diseases
Heart Diseases Antibodies	>5 publications with KNG1 and Heart Diseases
Atherosclerosis Antibodies	>5 publications with KNG1 and Atherosclerosis
Inflammation Antibodies	>3 publications with KNG1 and Inflammation
Kidney Diseases Antibodies	>2 publications with KNG1 and Kidney Diseases
Hypertension Antibodies	>2 publications with KNG1 and Hypertension
Nervous System Diseases Antibodies	>2 publications with KNG1 and Nervous System Diseases
Seizures Antibodies	>1 publications with KNG1 and Seizures
Liver Diseases Antibodies	>1 publications with KNG1 and Liver Diseases
Arrhythmias, Cardiac Antibodies	>1 publications with KNG1 and Arrhythmias, Cardiac

Organs/Tissues associated with KNG1 elisa kit

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>3 publications with KNG1 and Kidney
Liver Antibodies	>3 publications with KNG1 and Liver
Prostate Antibodies	>1 publications with KNG1 and Prostate
Brain Antibodies	>1 publications with KNG1 and Brain