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BAG Family Molecular Chaperone Regulator 1 (BAG1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1365374

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. This protein binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a… More details

$1070 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAG family molecular chaperone regulator 1 (Bag1), Recombinant Protein
Full Product Name
Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1)
Product Gene Name
Bag1 recombinant protein
Product Synonym Gene Name
Bag1
Sequence
MAGRSAARRP RGDREPLGPR LRAPRPAREP RQSESRAERG LPPSQRSSVR SAASGHDRST RGAPAGACKP RVKKKVRPRS SQSEKVGSSS RELTRSKKVT RSKNVTGTQV EEVTKIEEAT QTEEVTVAEE VTQTDNMAKT EEMVQTEEME TPRLSVIVTH SNERYDLLVT PQQGNSEPVV QDLAQLVEEA TGVPLPFQKL IFKGKSLKEM ETPLSALGMQ NGCRVMLIGE KSNPEEEVEL KKLKDLEVSA EKIANHLQEL NKELSGIQQG FLAKELQAEA LCKLDRKVKA TIEQFMKILE EIDTMVLPEQ FKDSRLKRKN LVKKVQVFLA ECDTVEQYIC QETERLQSTN LALAE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
24,875 Da
Sequence Positions
1-355, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q60739
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Bag1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bag1 purchase

MBS1365374 is a recombinant protein targeting Bag1. Also known as Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Bag1. It may not necessarily be applicable to this product.

NCBI GI #
284507286
NCBI GeneID
12017
NCBI Accession #
NP_001165210.1
UniProt Primary Accession #
Q60739
UniProt Secondary Accession #
Q561N1; Q6IS45; Q9D7K6
UniProt Related Accession #
Q60739
GenBank Nucleotide #
NM_001171739.1
NCBI Official Full Name
BAG family molecular chaperone regulator 1 isoform 1S
NCBI Official Synonym Full Names
BCL2-associated athanogene 1
NCBI Official Symbol
Bag1
NCBI Official Synonym Symbols
BAG-1; Rap46
UniProt Protein Name
BAG family molecular chaperone regulator 1
UniProt Synonym Protein Names
Bcl-2-associated athanogene 1
Protein Family
BAG family molecular chaperone regulator
UniProt Gene Name
Bag1
UniProt Synonym Gene Names
BAG-1
NCBI Protein Information
BAG family molecular chaperone regulator 1

NCBI Summary for Bag1

The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]
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UniProt Comments for Bag1

Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli ().
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Research Articles on Bag1

1. The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Bag1 recombinant protein

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with Bag1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >18 publications with Bag1 and Neoplasms
 Cysts Antibodies  >17 publications with Bag1 and Cysts
 Nervous System Diseases Antibodies  >13 publications with Bag1 and Nervous System Diseases
 Carcinoma Antibodies  >9 publications with Bag1 and Carcinoma
 Central Nervous System Diseases Antibodies  >8 publications with Bag1 and Central Nervous System Diseases
 Breast Neoplasms Antibodies  >7 publications with Bag1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Bag1 and Cardiovascular Diseases
 Fatigue Antibodies  >3 publications with Bag1 and Fatigue
 Cell Transformation, Neoplastic Antibodies  >3 publications with Bag1 and Cell Transformation, Neoplastic
 Depressive Disorder Antibodies  >3 publications with Bag1 and Depressive Disorder

Organs/Tissues associated with Bag1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >124 publications with Bag1 and Muscle
 Blood Antibodies  >22 publications with Bag1 and Blood
 Brain Antibodies  >22 publications with Bag1 and Brain
 Embryonic Tissue Antibodies  >13 publications with Bag1 and Embryonic Tissue
 Heart Antibodies  >9 publications with Bag1 and Heart
 Eye Antibodies  >7 publications with Bag1 and Eye
 Lung Antibodies  >4 publications with Bag1 and Lung
 Liver Antibodies  >4 publications with Bag1 and Liver
 Intestine Antibodies  >3 publications with Bag1 and Intestine
 Spleen Antibodies  >3 publications with Bag1 and Spleen
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