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1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-4 (PLCD4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1367818

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4), Recombinant Protein
Full Product Name
Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Product Gene Name
PLCD4 recombinant protein
Product Synonym Names
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
Sequence
MASLLQDQLT TDQDLLLMQE GMPMRKVRSK SWKKLRYFRL QNDGMTVWHA RQARGSAKPS FSISDVETIR NGHDSELLRS LAEELPLEQG FTIVFHGRRS NLDLMANSVE EAQIWMRGLQ LLVDLVTSMD HQERLDQWLS DWFQRGDKNQ DGKMSFQEVQ RLLHLMNVEM DQEYAFSLFQ AADTSQSGTL EGEEFVQFYK ALTKRAEVQE LFESFSADGQ KLTLLEFLDF LQEEQKERDC TSELALELID RYEPSDSGKL RHVLSMDGFL SYLCSKDGDI FNPACLPIYQ DMTQPLNHYF ICSSHNTYLV GDQLCGQSSV EGYIRALKRG CRCVEVDVWD GPSGEPVVYH GHTLTSRILF KDVVATVAQY AFQTSDYPVI LSLETHCSWE QQQTMARHLT EILGEQLLST TLDGVLPTQL PSPEELRRKI LVKGKKLTLE EDLEYEEEEA EPELEESELA LESQFETEPE PQEQNLQNKD KKKKSKPILC PALSSLVIYL KSVSFRSFTH SKEHYHFYEI SSFSETKAKR LIKEAGNEFV QHNTWQLSRV YPSGLRTDSS NYNPQELWNA GCQMVAMNMQ TAGLEMDICD GHFRQNGGCG YVLKPDFLRD IQSSFHPEKP ISPFKAQTLL IQVISGQQLP KVDKTKEGSI VDPLVKVQIF GVRLDTARQE TNYVENNGFN PYWGQTLCFR VLVPELAMLR FVVMDYDWKS RNDFIGQYTL PWTCMQQGYR HIHLLSKDGI SLRPASIFVY ICIQEGLEGD ES
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
103.6 kDa
Sequence Positions
1-762aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605939
3D Structure
ModBase 3D Structure for Q9BRC7

Product Categories/Family for PLCD4 recombinant protein

Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of PLCD4 recombinant protein

Human PLCD4 Recombinant Protein – Cat# MBS1367818

Product References and Citations for PLCD4 recombinant protein

Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.Leung D.W., Tompkins C., Brewer J., Ball A., Coon M., Morris V., Waggoner D., Singer J.W.Mol. Cancer 3:15-15(2004) Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization.Kim H., Suh P.-G., Ryu S.H., Park S.H.Cytogenet. Cell Genet. 87:254-255(1999) Expression of phospholipases A2 and C in human corneal epithelial cells.Landreville S., Coulombe S., Carrier P., Gelb M.H., Guerin S.L., Salesse C.Invest. Ophthalmol. Vis. Sci. 45:3997-4003(2004)

Other Notes

Small volumes of PLCD4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLCD4 purchase

MBS1367818 is a recombinant protein targeting PLCD4. Also known as Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCD4. It may not necessarily be applicable to this product.

NCBI GI #
14249340
NCBI GeneID
84812
NCBI Accession #
NP_116115.1
UniProt Primary Accession #
Q9BRC7
UniProt Secondary Accession #
Q53FS8
UniProt Related Accession #
Q9BRC7
GenBank Nucleotide #
NM_032726.3
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
NCBI Official Synonym Full Names
phospholipase C delta 4
NCBI Official Symbol
PLCD4
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
Protein Family
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name
PLCD4
UniProt Synonym Gene Names
hPLCD4; PLC-delta-4
UniProt Entry Name
PLCD4_HUMAN
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

NCBI Summary for PLCD4

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
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UniProt Comments for PLCD4

PLCD4: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; endoplasmic reticulum; nuclear membrane; plasma membrane

Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; signal transducer activity

Biological Process: acrosome reaction; lipid catabolic process; phosphatidylinositol metabolic process
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Research Articles on PLCD4

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLCD4 recombinant protein

 Reference Product  PubMed Publications
 DGKI recombinant protein  >1 publications with PLCD4 and DGKI
 DGKZ recombinant protein  >1 publications with PLCD4 and DGKZ

Pathways associated with PLCD4 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram

Diseases associated with PLCD4 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with PLCD4 and Nervous System Diseases
 Epilepsy Antibodies  >1 publications with PLCD4 and Epilepsy
 Breast Neoplasms Antibodies  >1 publications with PLCD4 and Breast Neoplasms
 Brain Diseases Antibodies  >1 publications with PLCD4 and Brain Diseases
 Hypertrophy Antibodies  >1 publications with PLCD4 and Hypertrophy

Organs/Tissues associated with PLCD4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with PLCD4 and Testis
 Liver Antibodies  >2 publications with PLCD4 and Liver
 Brain Antibodies  >2 publications with PLCD4 and Brain
 Heart Antibodies  >1 publications with PLCD4 and Heart
 Embryonic Tissue Antibodies  >1 publications with PLCD4 and Embryonic Tissue
 Muscle Antibodies  >1 publications with PLCD4 and Muscle
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