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Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1369357

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serinethreonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an… More details

$1065 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mitogen-activated protein kinase kinase kinase 14 (Map3k14), Recombinant Protein
Full Product Name
Recombinant Mouse Mitogen-activated protein kinase kinase kinase 14 (Map3k14) , partial
Product Gene Name
Map3k14 recombinant protein
Product Synonym Gene Name
Map3k14
Sequence
ALEKVPVEEY LVHALQGSVS SGQAHSLASL AKTWSSGSAK LQRLGPETED NEGVLLTEKL KPVDYEYREE VHWMTHQPRV GRGSFGEVHR MKDKQTGFQC AVKKVRLEVF RVEELVACAG LSSPRIVPLY GAVREGPWVN IFMELLEGGS LGQLIKQMGC LPEDRALYYL GQALEGLEYL HTRRILHGDV KADNVLLSSD GSRAALCDFG HALCLQPDGL GKSLLTGDYI PGTETHMAPE VVMGKPCDAK VDIWSSCCMM LHMLNGCHPW TQYFRGPLCL KIASEPPPIR EIPPSCAPLT AQAIQEGLRK EPVHRASAME LRRKVGKALQ EVGGLKSPWK GEYKEPR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
103,080 Da
Sequence Positions
329-675aa; Partial(include Protein kinase Domain)
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9WUL6
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Map3k14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Map3k14 purchase

MBS1369357 is a recombinant protein targeting Map3k14. Also known as Recombinant Mouse Mitogen-activated protein kinase kinase kinase 14 (Map3k14) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Map3k14. It may not necessarily be applicable to this product.

NCBI GI #
8393835
NCBI GeneID
53859
NCBI Accession #
NP_058592.1
UniProt Primary Accession #
Q9WUL6
UniProt Related Accession #
Q9WUL6
GenBank Nucleotide #
NM_016896.3
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase 14
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 14
NCBI Official Symbol
Map3k14
NCBI Official Synonym Symbols
Nik; aly
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 14
UniProt Synonym Protein Names
NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK
Protein Family
Mitogen-activated protein kinase kinase kinase
UniProt Gene Name
Map3k14
UniProt Synonym Gene Names
Nik
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 14

UniProt Comments for Map3k14

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Research Articles on Map3k14

1. These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Map3k14 recombinant protein

 Reference Product  PubMed Publications
 Ikbkb recombinant protein  >5 publications with Map3k14 and Ikbkb
 Traf3 recombinant protein  >3 publications with Map3k14 and Traf3
 Traf2 recombinant protein  >1 publications with Map3k14 and Traf2
 Tab2 recombinant protein  >1 publications with Map3k14 and Tab2
 Traf6 recombinant protein  >1 publications with Map3k14 and Traf6

Pathways associated with Map3k14 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram

Diseases associated with Map3k14 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >6 publications with Map3k14 and Necrosis
 Inflammation Antibodies  >6 publications with Map3k14 and Inflammation
 Diabetes Mellitus, Type 1 Antibodies  >1 publications with Map3k14 and Diabetes Mellitus, Type 1
 Insulin Resistance Antibodies  >1 publications with Map3k14 and Insulin Resistance
 Hypertension Antibodies  >1 publications with Map3k14 and Hypertension
 Diabetes Mellitus Antibodies  >1 publications with Map3k14 and Diabetes Mellitus
 Disease Models, Animal Antibodies  >1 publications with Map3k14 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with Map3k14 and Neoplasms, Experimental

Organs/Tissues associated with Map3k14 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with Map3k14 and Blood
 Bone Marrow Antibodies  >3 publications with Map3k14 and Bone Marrow
 Lung Antibodies  >2 publications with Map3k14 and Lung
 Liver Antibodies  >1 publications with Map3k14 and Liver
 Thymus Antibodies  >1 publications with Map3k14 and Thymus
 Connective Tissue Antibodies  >1 publications with Map3k14 and Connective Tissue
 Brain Antibodies  >1 publications with Map3k14 and Brain
 Spleen Antibodies  >1 publications with Map3k14 and Spleen
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