Mouse MASP2 Recombinant Protein – Cat# MBS1375096

Mannan-Binding Lectin Serine Protease 2 (MASP2) Mouse Recombinant Protein

Name: MASP2 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1375096
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1375096

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase More details

$335 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mannan-binding lectin serine protease 2 (Masp2), Recombinant Protein

Full Product Name

Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2)

Product Gene Name

Masp2 recombinant protein

Product Synonym Names

Mannan-binding lectin serine protease 2; EC=3.4.21.104; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2Cleaved into the following 2 chains:; 1. Mannan-binding lectin serine protease 2 A chain; 2. Mannan-bindi

Sequence

SKWPEPVFGR LVSPGFPEKY ADHQDRSWTL TAPPGYRLRL YFTHFDLELS YRCEYDFVKL SSGTKVLATL CGQESTDTEQ APGNDTFYSL GPSLKVTFHS DYSNEKPFTG FEAFYAAEDV DECRVSLGDS VPCDHYCHNY LGGYYCSCRA GYVLHQNKHT CSALCSGQVF TGRSGYLSSP EYPQPYPKLS SCTYSIRLED GFSVILDFVE SFDVETHPEA QCPYDSLKIQ TDKGEHGPFC GKTLPPRIET DSHKVTITFA TDESGNHTGW KIHYTSTARP CPDPTAPPNG SISPVQAIYV LKDRFSVFCK TGFELLQGSV PLKSFTAVCQ KDGSWDRPMP ECSIIDCGPP DDLPNGHVDY ITGPEVTTYK AVIQYSCEET FYTMSSNGKY VCEADGFWTS SKGEKLPPVC EPVCGLSTHT IGGRIVGGQP AKPGDFPWQV LLLGQTTAAA GALIHDNWVL TAAHAVYEKR MAASSLNIRM GILKRLSPHY TQAWPEEIFI HEGYTHGAGF DNDIALIKLK NKVTINGSIM PVCLPRKEAA SLMRTDFTGT VAGWGLTQKG LLARNLMFVD IPIADHQKCT AVYEKLYPGV RVSANMLCAG LETGGKDSCR GDSGGALVFL DNETQRWFVG GIVSWGSINC GAADQYGVYT KVINYIPWIE NIISNF

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

75.4 kDa

Sequence Positions

20-685aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q91WP0

Species

Mus musculus (Mouse)

Product Categories/Family for Masp2 recombinant protein

Cardiovascular

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Masp2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Masp2 purchase

MBS1375096 is a recombinant protein targeting Masp2. Also known as Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Masp2. It may not necessarily be applicable to this product.

NCBI GI #

54112422

NCBI GeneID

17175

NCBI Accession #

NP_001003893.1

UniProt Primary Accession #

Q91WP0

UniProt Secondary Accession #

Q9QXA4; Q9QXD2; Q9QXD5; Q9Z338; B1ARY2; B1ARY3

UniProt Related Accession #

Q91WP0

GenBank Nucleotide #

NM_001003893.2

NCBI Official Full Name

mannan-binding lectin serine protease 2 isoform 1

NCBI Official Synonym Full Names

mannan-binding lectin serine peptidase 2

NCBI Official Symbol

Masp2

NCBI Official Synonym Symbols

MAp19; MASP-2

UniProt Protein Name

Mannan-binding lectin serine protease 2

UniProt Synonym Protein Names

MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2

Protein Family

Mannan-binding lectin serine protease

UniProt Gene Name

Masp2

UniProt Synonym Gene Names

MASP-2

UniProt Entry Name

MASP2_MOUSE

NCBI Protein Information

mannan-binding lectin serine protease 2; MBL-associated serine protease 2; mannose-binding protein-associated serine protease 2

UniProt Comments for Masp2

MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.104; Secreted; Secreted, signal peptide; Protease

Cellular Component: extracellular region

Molecular Function: peptidase activity; protein binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; complement component C4b binding; calcium ion binding; calcium-dependent protein binding; catalytic activity

Biological Process: immune system process; innate immune response; proteolysis; complement activation, lectin pathway; complement activation, classical pathway; complement activation

Research Articles on Masp2

1. ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and C5aR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Masp2 recombinant protein

Reference Product	PubMed Publications
Masp1 recombinant protein	>67 publications with Masp2 and Masp1
Mbl2 recombinant protein	>34 publications with Masp2 and Mbl2
C4a recombinant protein	>1 publications with Masp2 and C4a

Pathways associated with Masp2 recombinant protein

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies	Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram

Diseases associated with Masp2 recombinant protein

Disease Name	Pubmed Publications
MASP2 Deficiency Antibodies	>47 publications with Masp2 and MASP2 Deficiency
Inflammation Antibodies	>27 publications with Masp2 and Inflammation
Liver Diseases Antibodies	>7 publications with Masp2 and Liver Diseases
Kidney Diseases Antibodies	>6 publications with Masp2 and Kidney Diseases
Hepatitis Antibodies	>5 publications with Masp2 and Hepatitis
Fibrosis Antibodies	>5 publications with Masp2 and Fibrosis
Brain Diseases Antibodies	>4 publications with Masp2 and Brain Diseases
Disease Models, Animal Antibodies	>4 publications with Masp2 and Disease Models, Animal
Nephritis Antibodies	>3 publications with Masp2 and Nephritis
Carcinoma, Hepatocellular Antibodies	>2 publications with Masp2 and Carcinoma, Hepatocellular

Organs/Tissues associated with Masp2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>18 publications with Masp2 and Liver
Lung Antibodies	>7 publications with Masp2 and Lung
Brain Antibodies	>6 publications with Masp2 and Brain
Bone Antibodies	>5 publications with Masp2 and Bone
Muscle Antibodies	>5 publications with Masp2 and Muscle
Intestine Antibodies	>2 publications with Masp2 and Intestine
Uncharacterized Tissue Antibodies	>1 publications with Masp2 and Uncharacterized Tissue
Testis Antibodies	>1 publications with Masp2 and Testis
Bone Marrow Antibodies	>1 publications with Masp2 and Bone Marrow
Embryonic Tissue Antibodies	>1 publications with Masp2 and Embryonic Tissue