Human COTL1 Recombinant Protein – Cat# MBS1377295

Coactosin-Like Protein (COTL1) Human Recombinant Protein

Name: COTL1 Recombinant Protein; Coactosin-Like Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1377295
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1377295

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Coactosin-like protein (COTL1), Recombinant Protein

Full Product Name

Recombinant Human Coactosin-like protein

Product Gene Name

COTL1 recombinant protein

Sequence

ATKIDKEACR AAYNLVRDDG SAVIWVTFKY DGSTIVPGEQ GAEYQHFIQQ CTDDVRLFAF VRFTTGDAMS KRSKFALITW IGENVSGLQR AKTGTDKTLV KEVVQNFAKE FVISDRKELE EDFIKSELKK AGGANYDAQT E

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

31.8 kDa

Sequence Positions

2-142aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606748

3D Structure

ModBase 3D Structure for Q14019

Product Categories/Family for COTL1 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for COTL1 recombinant protein

Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome.Chen K.-S., Manian P., Koeuth T., Potocki L., Zhao Q., Chinault A.C., Lee C.-C., Lupski J.R.Nat. Genet. 17:154-163(1997)

Other Notes

Small volumes of COTL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COTL1 purchase

MBS1377295 is a recombinant protein targeting COTL1. Also known as Recombinant Human Coactosin-like protein. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for COTL1. It may not necessarily be applicable to this product.

NCBI GI #

21624607

NCBI GeneID

23406

NCBI Accession #

NP_066972.1

UniProt Primary Accession #

Q14019

UniProt Secondary Accession #

Q86XM5; B2RDU3; D3DUL9

UniProt Related Accession #

Q14019

GenBank Nucleotide #

NM_021149.3

NCBI Official Full Name

coactosin-like protein

NCBI Official Synonym Full Names

coactosin-like F-actin binding protein 1

NCBI Official Symbol

COTL1

NCBI Official Synonym Symbols

CLP

UniProt Protein Name

Coactosin-like protein

Protein Family

Coactosin-like protein

UniProt Gene Name

COTL1

UniProt Synonym Gene Names

CLP

UniProt Entry Name

COTL1_HUMAN

NCBI Protein Information

coactosin-like protein

NCBI Summary for COTL1

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

UniProt Comments for COTL1

COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoplasm; cytoskeleton; nucleus

Molecular Function: actin binding; enzyme binding; protein binding

Biological Process: defense response to fungus

Research Articles on COTL1

1. The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COTL1 recombinant protein

Reference Product	PubMed Publications
ALOX5 recombinant protein	>10 publications with COTL1 and ALOX5
ALOX5AP recombinant protein	>2 publications with COTL1 and ALOX5AP

Diseases associated with COTL1 recombinant protein

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>4 publications with COTL1 and Lung Diseases
Lung Neoplasms Antibodies	>3 publications with COTL1 and Lung Neoplasms
Inflammation Antibodies	>2 publications with COTL1 and Inflammation

Organs/Tissues associated with COTL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with COTL1 and Blood
Lung Antibodies	>6 publications with COTL1 and Lung
Kidney Antibodies	>2 publications with COTL1 and Kidney
Liver Antibodies	>1 publications with COTL1 and Liver
Embryonic Tissue Antibodies	>1 publications with COTL1 and Embryonic Tissue
Placenta Antibodies	>1 publications with COTL1 and Placenta
Brain Antibodies	>1 publications with COTL1 and Brain