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Sodium Channel and Clathrin Linker 1 (SCLT1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1390516

MBS1390516 is a recombinant protein targeting SCLT1. Also known as Recombinant Human Sodium channel and clathrin linker 1 (SCLT1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1525 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sodium channel and clathrin linker 1 (SCLT1), Recombinant Protein
Full Product Name
Recombinant Human Sodium channel and clathrin linker 1 (SCLT1)
Product Gene Name
SCLT1 recombinant protein
Product Synonym Gene Name
SCLT1
Sequence
AAEIDFLREQ NRRLNEDFRR YQMESFSKYS SVQKAVCQGE GDDTFENLVF DQSFLAPLVT EYDKHLGELN GQLKYYQKQV GEMKLQLENV IKENERLHSE LKDAVEKKLE AFPLGTEVGT DIYADDETVR NLQEQLQLAN QEKTQAVELW QTVSQELDRL HKLYQEHMTE AQIHVFESQK QKDQLFDFQQ LTKQLHVTNE NMEVTNQQFL KTVTEQSVII EQLRKKLRQA KLELRVAVAK VEELTNVTED LQGQMKKKEK DVVSAHGREE ASDRRLQQLQ SSIKQLEIRL CVTIQEANQL RTENTHLEKQ TRELQAKCNE LENERYEAIV RARNSMQLLE EANLQKSQAL LEEKQKEEDI EKMKETVSRF VQDATIRTKK EVANTKKQCN IQISRLTEEL SALQMECAEK QGQIERVIKE KKAVEEELEK IYREGRGNES DYRKLEEMHQ RFLVSERSKD DLQLRLTRAE NRIKQLETDS SEEISRYQEM IQKLQNVLES ERENCGLVSE QRLKLQQENK QLRKETESLR KIALEAQKKA KVKISTMEHE FSIKERGFEV QLREMEDSNR NSIVELRHLL ATQQKAANRW KEETKKLTES AEIRINNLKS ELSRQKLHTQ ELLSQLEMAN EKVAENEKLI LEHQEKANRL QRRLSQAEER AASASQQLSV ITVQRRKAAS LMNLENI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
9,323 Da
Sequence Positions
2-688, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
611399
3D Structure
ModBase 3D Structure for Q96NL6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SCLT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCLT1. It may not necessarily be applicable to this product.

NCBI GI #
665386738
NCBI GeneID
132320
NCBI Accession #
NP_001287826.1
UniProt Primary Accession #
Q96NL6
UniProt Secondary Accession #
Q0VAH2; Q6P2M4; A4QN04
UniProt Related Accession #
Q96NL6
GenBank Nucleotide #
NM_001300897.1
NCBI Official Full Name
sodium channel and clathrin linker 1 isoform 2
NCBI Official Synonym Full Names
sodium channel and clathrin linker 1
NCBI Official Symbol
SCLT1
NCBI Official Synonym Symbols
CAP1A; CAP-1A
UniProt Protein Name
Sodium channel and clathrin linker 1
UniProt Synonym Protein Names
Sodium channel-associated protein 1
Protein Family
Sodium channel and clathrin linker
UniProt Gene Name
SCLT1
UniProt Synonym Gene Names
SAP1
NCBI Protein Information
sodium channel and clathrin linker 1

NCBI Summary for SCLT1

This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for SCLT1

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization ().

Research Articles on SCLT1

1. study identified 2 cases with a severe ciliopathy phenotype consistent with oro-facio-digital syndrome type IX; the autozygome of each index harbored a single truncating variant and the affected genes (SCLT1 and TBC1D32/C6orf170) have roles in centrosomal biology and ciliogenesis; findings suggest a role of SCLT1 and TBC1D32 in ciliopathy pathogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCLT1 recombinant protein

 Reference Product  PubMed Publications
 CEP164 recombinant protein  >3 publications with SCLT1 and CEP164
 FBF1 recombinant protein  >2 publications with SCLT1 and FBF1
 CEP89 recombinant protein  >2 publications with SCLT1 and CEP89
 CCDC41 recombinant protein  >2 publications with SCLT1 and CCDC41
 PHF17 recombinant protein  >1 publications with SCLT1 and PHF17

Pathways associated with SCLT1 recombinant protein

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with SCLT1 recombinant protein

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >2 publications with SCLT1 and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >1 publications with SCLT1 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with SCLT1 and Learning Disorders
 Heart Defects, Congenital Antibodies  >1 publications with SCLT1 and Heart Defects, Congenital
 Kidney Diseases Antibodies  >1 publications with SCLT1 and Kidney Diseases

Organs/Tissues associated with SCLT1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with SCLT1 and Kidney
 Skin Antibodies  >1 publications with SCLT1 and Skin
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