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Casein Kinase I Isoform Alpha (CSNK1A1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140221

Introduction: Caseine Kinase 1 alpha belongs is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. The CK1 isoforms - alpha, beta, gamma, delta, epsilon and their splice variants are involved in diverse… More details

$250 / 0.005 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Casein kinase I isoform alpha (CSNK1A1), Monoclonal Antibody
Full Product Name
Mouse Anti Human Casein kinase I isoform alpha
Product Gene Name
anti-CSNK1A1 antibody
Product Synonym Names
CSNK1A1 Antibody; Casein kinase I isoform alpha, Mouse Anti Human; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1; HLCDGP1; PRO2975
Clonality
Monoclonal
Isotype
IgG2b heavy chain and kappa light chain
Clone Number
PAT2E2AT
Host
Mouse
Form/Format
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Purity/Purification
CSNK1A1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
Molecular Weight
37,567 Da
OMIM
600505
Immunogen
Anti-human CSNK1A1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CSNK1A1 amino acids 1-337 purified from E Coli.

Product Categories/Family for anti-CSNK1A1 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme
Applications Tested/Suitable for anti-CSNK1A1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CSNK1A1 antibody
CSNK1A1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

Other Notes

Small volumes of anti-CSNK1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSNK1A1 purchase

MBS140221 is an antibody targeting CSNK1A1. Also known as Mouse Anti Human Casein kinase I isoform alpha. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CSNK1A1. It may not necessarily be applicable to this product.

NCBI GI #
68303575
NCBI GeneID
1452
NCBI Accession #
NP_001020276.1
UniProt Secondary Accession #
Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1
UniProt Related Accession #
P48729
GenBank Nucleotide #
NM_001025105.2
NCBI Official Full Name
casein kinase I isoform alpha isoform 1
NCBI Official Synonym Full Names
casein kinase 1, alpha 1
NCBI Official Symbol
CSNK1A1
NCBI Official Synonym Symbols
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
UniProt Protein Name
Casein kinase I isoform alpha
UniProt Synonym Protein Names
CK1
Protein Family
Casein kinase
UniProt Gene Name
CSNK1A1
UniProt Synonym Gene Names
CKI-alpha
UniProt Entry Name
KC1A_HUMAN
NCBI Protein Information
casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p

UniProt Comments for CSNK1A1

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CK1; EC 2.7.11.1; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: centrosome; membrane; cytoplasm; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity

Biological Process: regulation of cell shape; mitosis; peptidyl-serine phosphorylation; cell surface receptor linked signal transduction; Wnt receptor signaling pathway; cell division; signal transduction; protein amino acid phosphorylation; phagocytosis
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Research Articles on CSNK1A1

1. Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CSNK1A1 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >5 publications with CSNK1A1 and CTNNB1
 AXIN2 antibody  >1 publications with CSNK1A1 and AXIN2
 TP53 antibody  >1 publications with CSNK1A1 and TP53

Pathways associated with anti-CSNK1A1 antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Activation Of SMO Pathway antibodies  Activation Of SMO Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Degradation Of GLI2 By The Proteasome Pathway antibodies  Degradation Of GLI2 By The Proteasome Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram

Diseases associated with anti-CSNK1A1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CSNK1A1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with CSNK1A1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CSNK1A1 and Disease Models, Animal
 Esophageal Neoplasms Antibodies  >1 publications with CSNK1A1 and Esophageal Neoplasms
 Cognition Disorders Antibodies  >1 publications with CSNK1A1 and Cognition Disorders
 Anemia Antibodies  >1 publications with CSNK1A1 and Anemia
 Inflammation Antibodies  >1 publications with CSNK1A1 and Inflammation

Organs/Tissues associated with anti-CSNK1A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with CSNK1A1 and Lung
 Brain Antibodies  >2 publications with CSNK1A1 and Brain
 Lymph Node Antibodies  >1 publications with CSNK1A1 and Lymph Node
 Bone Antibodies  >1 publications with CSNK1A1 and Bone
 Intestine Antibodies  >1 publications with CSNK1A1 and Intestine
 Skin Antibodies  >1 publications with CSNK1A1 and Skin
 Blood Antibodies  >1 publications with CSNK1A1 and Blood
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