Human PEPD cDNA Clone Expression Plasmid – Cat# MBS1278774

PEPD cDNA Clone – Peptidase D (Human)

Name: PEPD cDNA Clone; Peptidase D; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1278774
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278774

MBS1278774 is a cDNA clone targeting PEPD. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PEPD, cDNA Clone

Full Product Name

PEPD cDNA Clone

Product Gene Name

PEPD cdna clone

Sequence

atggcggcgg ccaccggacc ctcgttttgg ctggggaatg aaaccctgaa ggtgccgctg gcgctctttg ccttgaaccg gcagcgcctg tgtgagcggc tgcggaagaa ccctgctgtg caggccggct ccatcgtggt cctgcagggc ggggaggaga ctcagcgcta ctgcaccgac accggggtcc tcttccgcca ggagtccttc tttcactggg cgttcggtgt cactgagcca ggctgctatg gtgtcatcga tgttgacact gggaagtcga ccctgtttgt gcccaggctt cctgccagcc atgccacctg gatgggaaag atccattcca aggagcactt caaggagaag tatgccgtgg acgacgtcca gtacgtagat gagattgcca gcgtcctgac gtcacagaag ccctctgtcc tcctcacttt gcgtggcgtc aacacggaca gcggcagtgt ctgcagggag gcctcctttg acggcatcag caagttcgaa gtcaacaata ccattcttca cccagagatc gttgagtgcc gagtgtttaa gacggatatg gagctggagg ttctgcgcta taccaataaa atctccagcg aggcccaccg tgaggtaatg aaggctgtaa aagtgggaat gaaagaatat gagttggaaa gcctcttcga gcactactgc tactcccggg gcggcatgcg ccacagctcc tacacctgca tctgcggcag tggtgagaac tcagccgtgc tacactacgg acacgccgga gctcccaacg accgaacgat ccagaatggg gatatgtgcc tgttcgacat gggcggtgag tattactgct tcgcttccga catcacctgc tcctttcccg ccaacggcaa gttcactgca gaccagaagg ccgtctatga ggcagtgctg cggagctccc gtgccgtcat gggtgccatg aagccaggtg tctggtggcc tgacatgcac cgcctggctg accgcatcca cctggaggag ctggcccaca tgggcatcct gagcggcagc gtggacgcca tggtccaggc tcacctgggg gccgtgttta tgcctcacgg gcttggccac ttcctgggca ttgacgtgca cgacgtggga ggctacccag agggcgtgga gcgcatcgac gagcccggcc tgcggagcct gcgcactgca cggcacctgc agccaggcat ggtgctcacc gtggagccgg gcatctactt catcgaccac ctcctggatg aggccctggc ggacccggcc cgcgcctcct tccttaaccg cgaggtcctg cagcgctttc gcggttttgg cggggtccgc atcgaggagg acgtcgtggt gactgacagc ggcatagagc tgctgacctg cgtgccccgc actgtggaag agattgaagc atgcatggca ggctgtgaca aggcctttac ccccttctct ggccccaagt ag

Molecular Weight

47,261 Da

OMIM

170100

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PEPD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PEPD. It may not necessarily be applicable to this product.

NCBI GI #

13279181

NCBI GeneID

5184

NCBI Accession #

BC004305

UniProt Secondary Accession #

Q8TBN9; Q9BT75; A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8

UniProt Related Accession #

P12955

NCBI Official Full Name

Homo sapiens peptidase D, mRNA

NCBI Official Synonym Full Names

peptidase D

NCBI Official Symbol

PEPD

NCBI Official Synonym Symbols

PROLIDASE

UniProt Protein Name

Xaa-Pro dipeptidase

UniProt Synonym Protein Names

Imidodipeptidase; Peptidase D; Proline dipeptidase; Prolidase

Protein Family

Cytosol non-specific dipeptidase

UniProt Gene Name

PEPD

UniProt Synonym Gene Names

PRD; X-Pro dipeptidase; Prolidase

UniProt Entry Name

PEPD_HUMAN

NCBI Protein Information

xaa-Pro dipeptidase

NCBI Summary for PEPD

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

UniProt Comments for PEPD

peptidase D: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Defects in PEPD are a cause of prolidase deficiency (PD). Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait. Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.13.9

Chromosomal Location of Human Ortholog: 19q13.11

Molecular Function: metallocarboxypeptidase activity; protein binding

Biological Process: amino acid metabolic process

Disease: Prolidase Deficiency

Research Articles on PEPD

1. absence of prolidase activity in pterygium tissue indicates that there is no collagen turnover in this tissue

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with PEPD cdna clone

Disease Name	Pubmed Publications
Prolidase Deficiency Antibodies	>19 publications with PEPD and Prolidase Deficiency
Cardiovascular Diseases Antibodies	>9 publications with PEPD and Cardiovascular Diseases
Infection Antibodies	>4 publications with PEPD and Infection
Splenomegaly Antibodies	>4 publications with PEPD and Splenomegaly
Hypertrophy Antibodies	>3 publications with PEPD and Hypertrophy
Skin Ulcer Antibodies	>3 publications with PEPD and Skin Ulcer
Respiratory Tract Diseases Antibodies	>3 publications with PEPD and Respiratory Tract Diseases
Neoplasms Antibodies	>3 publications with PEPD and Neoplasms
Drug Toxicity Antibodies	>2 publications with PEPD and Drug Toxicity
Diabetes Mellitus, Type 2 Antibodies	>2 publications with PEPD and Diabetes Mellitus, Type 2

Organs/Tissues associated with PEPD cdna clone

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>16 publications with PEPD and Skin
Blood Antibodies	>10 publications with PEPD and Blood
Ganglia Antibodies	>6 publications with PEPD and Ganglia
Muscle Antibodies	>5 publications with PEPD and Muscle
Kidney Antibodies	>3 publications with PEPD and Kidney
Nerve Antibodies	>2 publications with PEPD and Nerve
Pancreas Antibodies	>1 publications with PEPD and Pancreas
Ovary Antibodies	>1 publications with PEPD and Ovary
Bladder Antibodies	>1 publications with PEPD and Bladder
Embryonic Tissue Antibodies	>1 publications with PEPD and Embryonic Tissue