Mouse Anti-PDPN Monoclonal Antibody – Cat# MBS140296

Podoplanin (PDPN) Antibody – Mouse Monoclonal

Name: PDPN Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS140296
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140296

Introduction: Podoplanin is a small mucin-like type-1 transmembrane protein, typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Podoplanin (PDPN), Monoclonal Antibody

Full Product Name

Mouse Anti Human Podoplanin

Product Gene Name

anti-PDPN antibody

Product Synonym Names

PDPN Antibody; Podoplanin, Mouse Anti Human; Podoplanin; Glycoprotein 36; PA2.26 antigen; T1A; GP36; GP40; Gp38; OTS8; T1A2; HT1A-1; PA2.26; T1-alpha; PDPN

Clonality

Monoclonal

Isotype

IgG2b heavy chain and kappa light chain

Clone Number

P5E2AT

Host

Mouse

Form/Format

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile filtered colorless solution.

Purity/Purification

PDPN antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

Preparation and Storage

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.

Molecular Weight

12,421 Da

OMIM

608863

Immunogen

Anti-human PDPN mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDPN amino acids 1-206 purified from E Coli.

Product Categories/Family for anti-PDPN antibody

Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies

Applications Tested/Suitable for anti-PDPN antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-PDPN antibody

PDPN antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

Other Notes

Small volumes of anti-PDPN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDPN purchase

MBS140296 is an antibody targeting PDPN. Also known as Mouse Anti Human Podoplanin. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PDPN. It may not necessarily be applicable to this product.

NCBI GI #

21666312

NCBI Accession #

AAM73655.1

UniProt Secondary Accession #

O60836; O95128; Q7L375; Q8NBQ8; Q8NBR3; A9Z1Y2; B2R6J8; E9PB68; F6QWX5

NCBI Official Full Name

podoplanin

UniProt Protein Name

Podoplanin

UniProt Synonym Protein Names

Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A

Protein Family

Podoplanin

UniProt Gene Name

PDPN

UniProt Synonym Gene Names

Gp36; T1A

UniProt Entry Name

PDPN_HUMAN

NCBI Summary for PDPN

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for PDPN

PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: ruffle; filopodium membrane; microvillus membrane; lamellipodium; integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane; filopodium

Molecular Function: folic acid transporter activity; water transporter activity; water channel activity; amino acid transmembrane transporter activity

Biological Process: nervous system development; water transport; cell morphogenesis; positive regulation of cell motility; signal transduction; folic acid transport; prostaglandin metabolic process; cell proliferation; regulation of cell shape; cell-cell adhesion; response to hyperoxia; amino acid transport; lymphangiogenesis; tube morphogenesis; inflammatory response; alveolus development; positive regulation of cell migration; lung development

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.