Human GP6 Recombinant Protein – Cat# MBS1403339

Platelet Glycoprotein VI (GP6) Human Recombinant Protein

Name: GP6 Recombinant Protein; Platelet Glycoprotein VI; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1403339
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1403339

MBS1403339 is a recombinant protein targeting GP6. Also known as Recombinant Human Platelet glycoprotein VI (GP6), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$460 / 0.02 mg (Mammalian-Cell) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Platelet glycoprotein VI (GP6), Recombinant Protein

Full Product Name

Recombinant Human Platelet glycoprotein VI (GP6), partial

Product Gene Name

GP6 recombinant protein

Product Synonym Gene Name

GP6

Sequence

QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELVATGV FAKPSLSAQP GPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC YSFSSRDPYL WSAPSDPLEL VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT TETSRSITAS PKESDSPAGP ARQYYTK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

67,476 Da

Sequence Positions

21-267

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

605546

3D Structure

ModBase 3D Structure for Q9HCN6

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GP6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GP6. It may not necessarily be applicable to this product.

NCBI GI #

563580292

NCBI GeneID

51206

NCBI Accession #

NP_001077368.2

UniProt Primary Accession #

Q9HCN6

UniProt Secondary Accession #

Q9HCN7; Q9UIF2

UniProt Related Accession #

Q9HCN6

GenBank Nucleotide #

NM_001083899.2

NCBI Official Full Name

platelet glycoprotein VI isoform 1

NCBI Official Synonym Full Names

glycoprotein VI platelet

NCBI Official Symbol

GP6

NCBI Official Synonym Symbols

GPIV; GPVI; BDPLT11

UniProt Protein Name

Platelet glycoprotein VI

UniProt Synonym Protein Names

Glycoprotein 6

Protein Family

Platelet glycoprotein

UniProt Gene Name

GP6

UniProt Synonym Gene Names

GPVICurated

NCBI Protein Information

platelet glycoprotein VI

NCBI Summary for GP6

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

UniProt Comments for GP6

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Research Articles on GP6

1. Platelet adhesion to collagen induces GPVI dimer clustering. GPVI clustering increases both avidity for collagen and the proximity of GPVI-associated signaling molecules, which may be crucial for the initiation and persistence of signaling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GP6 recombinant protein

Reference Product	PubMed Publications
CRP recombinant protein	>2 publications with GP6 and CRP
LYN recombinant protein	>1 publications with GP6 and LYN
FYN recombinant protein	>1 publications with GP6 and FYN

Pathways associated with GP6 recombinant protein

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
GPVI-mediated Activation Cascade Pathway antibodies	GPVI-mediated Activation Cascade Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Platelet Adhesion To Exposed Collagen Pathway antibodies	Platelet Adhesion To Exposed Collagen Pathway Diagram
Platelet Activation Pathway antibodies	Platelet Activation Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with GP6 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>152 publications with GP6 and Carcinoma
Adenocarcinoma Antibodies	>29 publications with GP6 and Adenocarcinoma
Vascular Diseases Antibodies	>17 publications with GP6 and Vascular Diseases
Precancerous Conditions Antibodies	>13 publications with GP6 and Precancerous Conditions
Hyperplasia Antibodies	>9 publications with GP6 and Hyperplasia
Breast Neoplasms Antibodies	>6 publications with GP6 and Breast Neoplasms
Neoplasm Invasiveness Antibodies	>6 publications with GP6 and Neoplasm Invasiveness
Colorectal Neoplasms Antibodies	>6 publications with GP6 and Colorectal Neoplasms
Heart Diseases Antibodies	>5 publications with GP6 and Heart Diseases
Cell Transformation, Neoplastic Antibodies	>5 publications with GP6 and Cell Transformation, Neoplastic

Organs/Tissues associated with GP6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Mouth Antibodies	>30 publications with GP6 and Mouth
Skin Antibodies	>9 publications with GP6 and Skin
Placenta Antibodies	>4 publications with GP6 and Placenta
Muscle Antibodies	>3 publications with GP6 and Muscle
Intestine Antibodies	>2 publications with GP6 and Intestine
Pharynx Antibodies	>2 publications with GP6 and Pharynx