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CD3E Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140485

CD3-epsilonpolypeptide (CD3E) along with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, creates the T-cell receptor-CD3 complex. This complex has an imperative role in coupling antigen recognition to a number of… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3E, Monoclonal Antibody
Full Product Name
Mouse Anti Human CD3E
Product Gene Name
anti-CD3E antibody
Product Synonym Names
CD3E Antibody; CD3E, Mouse Anti Human; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e; T3E; TCRE
Clonality
Monoclonal
Clone Number
PAT3H3AT
Host
Mouse
Species Reactivity
Human
Form/Format
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Preparation and Storage
Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Molecular Weight
23,147 Da
OMIM
186830
Ig Subclass
Mouse IgG1 heavy chain and k light chain.
Immunogen
Anti-human CD3E mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD3E protein 23-126 amino acids purified from E Coli.

Product Categories/Family for anti-CD3E antibody

Monoclonal Antibodies; Anti-Human LYMPHOCYTES
Applications Tested/Suitable for anti-CD3E antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CD3E antibody
CD3E antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.

Other Notes

Small volumes of anti-CD3E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3E purchase

MBS140485 is an antibody targeting CD3E. Also known as Mouse Anti Human CD3E. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3E. It may not necessarily be applicable to this product.

NCBI GI #
119587768
NCBI GeneID
916
NCBI Accession #
EAW67364.1
UniProt Secondary Accession #
A8K997
UniProt Related Accession #
P07766
NCBI Official Full Name
CD3e antigen, epsilon polypeptide (TiT3 complex), isoform CRA_e
NCBI Official Synonym Full Names
CD3e molecule
NCBI Official Symbol
CD3E
NCBI Official Synonym Symbols
T3E; TCRE; IMD18
UniProt Protein Name
T-cell surface glycoprotein CD3 epsilon chain
UniProt Synonym Protein Names
T-cell surface antigen T3/Leu-4 epsilon chain; CD_antigen: CD3e
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3E
UniProt Synonym Gene Names
T3E
UniProt Entry Name
CD3E_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 epsilon chain

UniProt Comments for CD3E

CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: external side of plasma membrane; plasma membrane; T cell receptor complex

Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; SH3 domain binding

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of T cell proliferation; regulation of immune response; signal complex assembly; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Immunodeficiency 18
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD3E antibody

 Reference Product  PubMed Publications
 LCK antibody  >20 publications with CD3E and LCK
 ZAP70 antibody  >20 publications with CD3E and ZAP70
 CD3D antibody  >15 publications with CD3E and CD3D
 CD3G antibody  >9 publications with CD3E and CD3G
 LAT antibody  >7 publications with CD3E and LAT
 SYK antibody  >4 publications with CD3E and SYK
 CD247 antibody  >3 publications with CD3E and CD247
 CSK antibody  >2 publications with CD3E and CSK

Pathways associated with anti-CD3E antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD3E antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >22 publications with CD3E and Inflammation
 Disease Models, Animal Antibodies  >19 publications with CD3E and Disease Models, Animal
 Necrosis Antibodies  >14 publications with CD3E and Necrosis
 Immunologic Deficiency Syndromes Antibodies  >14 publications with CD3E and Immunologic Deficiency Syndromes
 Carcinoma Antibodies  >7 publications with CD3E and Carcinoma
 Vascular Diseases Antibodies  >6 publications with CD3E and Vascular Diseases
 Lung Diseases Antibodies  >5 publications with CD3E and Lung Diseases
 Severe Combined Immunodeficiency Antibodies  >5 publications with CD3E and Severe Combined Immunodeficiency
 Arthritis, Rheumatoid Antibodies  >5 publications with CD3E and Arthritis, Rheumatoid
 Cell Transformation, Neoplastic Antibodies  >4 publications with CD3E and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-CD3E antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >203 publications with CD3E and Blood
 Thymus Antibodies  >48 publications with CD3E and Thymus
 Spleen Antibodies  >36 publications with CD3E and Spleen
 Lymph Node Antibodies  >17 publications with CD3E and Lymph Node
 Liver Antibodies  >13 publications with CD3E and Liver
 Intestine Antibodies  >11 publications with CD3E and Intestine
 Kidney Antibodies  >7 publications with CD3E and Kidney
 Brain Antibodies  >6 publications with CD3E and Brain
 Lung Antibodies  >6 publications with CD3E and Lung
 Heart Antibodies  >5 publications with CD3E and Heart
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