SLAMF1 cDNA Clone – Signaling Lymphocytic Activation Molecule Family Member 1 (Human)

SLAM: a type I membrane protein present on the surface of B cells, T cells and CD83+ dendritic cells. A high-affinity self-ligand considered to be important in bidirectional T <-> B-cell stimulation. SLAM-induced signal-transduction events in T lymphocytes are different from those in B cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A (SAP) acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (SHP-2)-dependent signal transduction operates. Its cytoplasmic domain interacts with SAP through part of its SH2 domain, and with SHP-2. Three alternatively spliced isoforms have been described.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.3

Molecular Function: antigen binding; protein binding; transmembrane receptor activity

Biological Process: myeloid dendritic cell activation during immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; positive regulation of cell proliferation; positive regulation of JNK cascade