Mouse Anti-PKM2 Monoclonal Antibody – Cat# MBS140517

Tumor Type M2 Pyruvate Kinase (PKM2) Antibody – Mouse Monoclonal

Name: PKM2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS140517
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140517

Pyruvate kinase is a key enzyme in the glycolytic pathway. The M2 isoenzyme of pyruvate kinase is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. The marker is useful for measuring… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Tumor Type M2 Pyruvate Kinase (PKM2), Monoclonal Antibody

Full Product Name

Mouse Anti Human Tumor Type M2 Pyruvate Kinase, Clone PAT1B10AT

Product Gene Name

anti-PKM2 antibody

Product Synonym Names

PKM2 PAT1B10AT Antibody; Tumor Type M2 Pyruvate Kinase, Clone PAT1B10AT, Mouse Anti Human; Pyruvate kinase isozymes M1/M2; EC 2.7.1.40; Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; CTHBP; THBP1; M2PK; PKM2; PK3; PK2; PKM; TCB; OIP3; MGC3932; Tumor Type M2 Pyruvate Kinase

Clonality

Monoclonal

Clone Number

PAT1B10AT

Host

Mouse

Species Reactivity

Human

Form/Format

1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.

Purity/Purification

Purified from mouse ascitic fluids by protein-A affinity chromatography

Preparation and Storage

Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.

Molecular Weight

55,914 Da

Ig Subclass

Mouse IgG1 heavy chain and k light chain.

Immunogen

Anti-human PKM2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PKM2 protein 1-531 amino acids purified from E Coli.

Product Categories/Family for anti-PKM2 antibody

Monoclonal Antibodies; Anti-Human Enzymes

Applications Tested/Suitable for anti-PKM2 antibody

ELISA (EIA), Western Blot (WB) Immunofluorescence (IF)

Application Notes for anti-PKM2 antibody

PKM2 antibody has been tested by ELISA, Western blot analysis and Immunofluorescence analysis to assure specificity and reactivity.

Other Notes

Small volumes of anti-PKM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PKM2 purchase

MBS140517 is an antibody targeting PKM2. Also known as Mouse Anti Human Tumor Type M2 Pyruvate Kinase, Clone PAT1B10AT. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PKM2. It may not necessarily be applicable to this product.

NCBI GI #

751368110

NCBI GeneID

23087

NCBI Accession #

NP_001291424.1

UniProt Secondary Accession #

Q86XQ0; Q8WVA4

UniProt Related Accession #

Q9UPQ4

GenBank Nucleotide #

NM_001304495.1

NCBI Official Full Name

tripartite motif-containing protein 35 isoform 2

NCBI Official Synonym Full Names

tripartite motif containing 35

NCBI Official Symbol

TRIM35

NCBI Official Synonym Symbols

HLS5; MAIR

UniProt Protein Name

Tripartite motif-containing protein 35

UniProt Synonym Protein Names

Hemopoietic lineage switch protein 5

UniProt Gene Name

TRIM35

UniProt Synonym Gene Names

HLS5; KIAA1098

UniProt Entry Name

TRI35_HUMAN

NCBI Protein Information

tripartite motif-containing protein 35

UniProt Comments for PKM2

TRIM35: May play a role as a tumor suppressor. Implicated in the cell death mechanism. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: cytoplasm; nucleus

Biological Process: apoptosis; innate immune response; negative regulation of mitotic cell cycle; positive regulation of apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PKM2 antibody

Reference Product	PubMed Publications
ZFPM1 antibody	>1 publications with PKM2 and ZFPM1

Pathways associated with anti-PKM2 antibody

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
Interferon Gamma Signaling Pathway antibodies	Interferon Gamma Signaling Pathway Diagram

Diseases associated with anti-PKM2 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>4 publications with PKM2 and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>4 publications with PKM2 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>4 publications with PKM2 and Liver Neoplasms
Liver Diseases Antibodies	>4 publications with PKM2 and Liver Diseases
Disease Models, Animal Antibodies	>1 publications with PKM2 and Disease Models, Animal
Necrosis Antibodies	>1 publications with PKM2 and Necrosis

Organs/Tissues associated with anti-PKM2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4 publications with PKM2 and Liver
Bone Antibodies	>2 publications with PKM2 and Bone
Thyroid Antibodies	>2 publications with PKM2 and Thyroid
Embryonic Tissue Antibodies	>1 publications with PKM2 and Embryonic Tissue
Kidney Antibodies	>1 publications with PKM2 and Kidney
Brain Antibodies	>1 publications with PKM2 and Brain