Human CFD Recombinant Protein – Cat# MBS140678

Complement Factor D (CFD) Human Recombinant Protein

Name: CFD Recombinant Protein; Complement Factor D; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140678
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140678

Introduction: Complement Factor D (Adipsin), which belongs to the trypsin family of peptidases, is involved in the alternative complement pathway of the complement system where it cleaves factor B. In the alternative complement pathway, Adipsin is best known… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement Factor D (CFD), Recombinant Protein

Full Product Name

Recombinant Human Complement Factor D, sf9

Product Gene Name

CFD recombinant protein

Product Synonym Names

Adipsin Human, Sf9; Complement Factor D Human Recombinant, Sf9; Complement Factor D (Adipsin); Properdin Factor D; D Component Of Complement (Adipsin); C3 Convertase Activator; EC 3.4.21.46; ADIPSIN; PFD; AND; DF; Complement Factor D Preproprotein; Complement Factor D; EC 3.4.21; Complement factor D

Sequence

PPRGRILGGR EAEAHARPYM ASVQLNGAHL CGGVLVAEQW VLSAAHCLED AADGKVQVLL GAHSLSQPEP SKRLYDVLRA VPHPDSQPDT IDHDLLLLQL SEKATLGPAV RPLPWQRVDR DVAPGTLCDV AGWGIVNHAG RRPDSLQHVL LPVLDRATCN RRTHHDGAIT ERLMCAESNR RDSCKGDSGG PLVCGGVLEG VVTSGSRVCG NRKKPGIYTR VASYAAWIDS VLAVEHH HHH H

Host

Sf9 Baculovirus Cells

Form/Format

Adipsin protein solution (1mg/ml) contains phosphate buffered saline (pH7.4).
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

27,033 Da

OMIM

134350

3D Structure

ModBase 3D Structure for P00746

Product Categories/Family for CFD recombinant protein

Recombinant & Natural Proteins

Other Notes

Small volumes of CFD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFD purchase

MBS140678 is a recombinant protein targeting CFD. Also known as Recombinant Human Complement Factor D, sf9. Host: Sf9 Baculovirus Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CFD. It may not necessarily be applicable to this product.

NCBI GI #

955654851

NCBI GeneID

1675

NCBI Accession #

NP_001304264.1

UniProt Primary Accession #

P00746

UniProt Secondary Accession #

Q5U5S1; Q86VJ5; Q8N4E0; Q8WZB4; B4DV76

UniProt Related Accession #

P00746

GenBank Nucleotide #

NM_001317335.1

NCBI Official Full Name

complement factor D isoform 2

NCBI Official Synonym Full Names

complement factor D (adipsin)

NCBI Official Symbol

CFD

NCBI Official Synonym Symbols

DF; ADN; PFD; ADIPSIN

UniProt Protein Name

Complement factor D

UniProt Synonym Protein Names

Adipsin; C3 convertase activator; Properdin factor D

Protein Family

Complement factor

UniProt Gene Name

CFD

UniProt Synonym Gene Names

DF; PFD

UniProt Entry Name

CFAD_HUMAN

NCBI Protein Information

complement factor D

UniProt Comments for CFD

CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.46; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: complement activation; complement activation, alternative pathway; platelet degranulation

Disease: Complement Factor D Deficiency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CFD recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Alternative Complement Activation Pathway antibodies	Alternative Complement Activation Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with CFD recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>462 publications with CFD and Cardiovascular Diseases
Heart Diseases Antibodies	>134 publications with CFD and Heart Diseases
Hyperplasia Antibodies	>35 publications with CFD and Hyperplasia
Carcinoma Antibodies	>22 publications with CFD and Carcinoma
Disease Models, Animal Antibodies	>21 publications with CFD and Disease Models, Animal
Inflammation Antibodies	>20 publications with CFD and Inflammation
Hypertension Antibodies	>20 publications with CFD and Hypertension
Liver Diseases Antibodies	>14 publications with CFD and Liver Diseases
Kidney Diseases Antibodies	>10 publications with CFD and Kidney Diseases
Hypertrophy Antibodies	>9 publications with CFD and Hypertrophy

Organs/Tissues associated with CFD recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>818 publications with CFD and Blood
Vascular Antibodies	>542 publications with CFD and Vascular
Heart Antibodies	>317 publications with CFD and Heart
Lung Antibodies	>123 publications with CFD and Lung
Brain Antibodies	>94 publications with CFD and Brain
Bone Antibodies	>78 publications with CFD and Bone
Mouth Antibodies	>61 publications with CFD and Mouth
Liver Antibodies	>36 publications with CFD and Liver
Muscle Antibodies	>35 publications with CFD and Muscle
Pharynx Antibodies	>28 publications with CFD and Pharynx