Mouse CLEC4E Recombinant Protein – Cat# MBS1408349

C-Type Lectin Domain Family 4 Member E (CLEC4E) Mouse Recombinant Protein

Name: CLEC4E Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1408349
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1408349

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose… More details

$575 / 0.02 mg (Baculovirus) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C-type lectin domain family 4 member E (Clec4e), Recombinant Protein

Full Product Name

Recombinant Mouse C-type lectin domain family 4 member E (Clec4e)

Product Gene Name

Clec4e recombinant protein

Product Synonym Gene Name

Clec4e; Clecsf9; Mincle

Product Synonym Names

C-type lectin domain family 4 member E; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin

Sequence

TYRSSQISGQ NLQPHRNIKE LSCYSEASGS VKNCCPLNWK HYQSSCYFFS TTTLTWSSSL KNCSDMGAHL VVIDTQEEQE FLFRTKPKRK EFYIGLTDQV VEGQWQWVDD TPFTESLSFW DAGEPNNIVL VEDCATIRDS SNSRKNWNDI PCFYSMPWIC EMPEISPLD

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

23.6 kDa

Sequence Positions

46-214aa; Extracellular Domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q9R0Q8

Species

Mus musculus (Mouse)

Product Categories/Family for Clec4e recombinant protein

Immunology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Clec4e recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Clec4e purchase

MBS1408349 is a recombinant protein targeting Clec4e. Also known as Recombinant Mouse C-type lectin domain family 4 member E (Clec4e). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Clec4e. It may not necessarily be applicable to this product.

NCBI GI #

9910162

NCBI GeneID

56619

NCBI Accession #

NP_064332.1

UniProt Primary Accession #

Q9R0Q8

UniProt Related Accession #

Q9R0Q8

GenBank Nucleotide #

NM_019948.2

NCBI Official Full Name

C-type lectin domain family 4 member E

NCBI Official Synonym Full Names

C-type lectin domain family 4, member e

NCBI Official Symbol

Clec4e

NCBI Official Synonym Symbols

C86253; Mincle; Clecsf9

UniProt Protein Name

C-type lectin domain family 4 member E

UniProt Synonym Protein Names

C-type lectin superfamily member 9; Macrophage-inducible C-type lectin

Protein Family

C-type lectin domain family

UniProt Gene Name

Clec4e

UniProt Synonym Gene Names

Clecsf9; Mincle

UniProt Entry Name

CLC4E_MOUSE

NCBI Protein Information

C-type lectin domain family 4 member E; C-type lectin superfamily member 9; macrophage-inducible C-type lectin; C-type lectin, superfamily member 9; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9

UniProt Comments for Clec4e

CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: immune system process; immune response; positive regulation of cytokine secretion

Research Articles on Clec4e

1. These results demonstrate protective role of Mincle in host defense against K. pneumoniae pneumonia by coordinating bacterial clearance mechanisms of neutrophils.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Clec4e recombinant protein

Reference Product	PubMed Publications
Clec4d recombinant protein	>6 publications with Clec4e and Clec4d
Tlr2 recombinant protein	>2 publications with Clec4e and Tlr2
Il1b recombinant protein	>2 publications with Clec4e and Il1b

Pathways associated with Clec4e recombinant protein

Products by Pathway	Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with Clec4e recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>6 publications with Clec4e and Inflammation
Necrosis Antibodies	>3 publications with Clec4e and Necrosis
Disease Models, Animal Antibodies	>2 publications with Clec4e and Disease Models, Animal
Skin Diseases Antibodies	>2 publications with Clec4e and Skin Diseases
Kidney Diseases Antibodies	>1 publications with Clec4e and Kidney Diseases
Heart Diseases Antibodies	>1 publications with Clec4e and Heart Diseases
Pneumonia Antibodies	>1 publications with Clec4e and Pneumonia
Liver Diseases Antibodies	>1 publications with Clec4e and Liver Diseases
Atherosclerosis Antibodies	>1 publications with Clec4e and Atherosclerosis
Weight Loss Antibodies	>1 publications with Clec4e and Weight Loss

Organs/Tissues associated with Clec4e recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with Clec4e and Blood
Bone Antibodies	>3 publications with Clec4e and Bone
Bone Marrow Antibodies	>3 publications with Clec4e and Bone Marrow
Spleen Antibodies	>1 publications with Clec4e and Spleen
Skin Antibodies	>1 publications with Clec4e and Skin