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Unconventional Myosin-Ixb (MYO9B) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1408558

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Unconventional myosin-IXb (Myo9b), Recombinant Protein
Full Product Name
Recombinant Rat Unconventional myosin-IXb (Myo9b) , partial
Product Gene Name
Myo9b recombinant protein
Product Synonym Gene Name
Myo9b
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
225,037 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q63358
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Myo9b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Myo9b purchase

MBS1408558 is a recombinant protein targeting Myo9b. Also known as Recombinant Rat Unconventional myosin-IXb (Myo9b) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Myo9b. It may not necessarily be applicable to this product.

NCBI GI #
14548111
NCBI GeneID
25486
NCBI Accession #
Q63358.1
UniProt Primary Accession #
Q63358
UniProt Related Accession #
Q63358
NCBI Official Full Name
Unconventional myosin-IXb
NCBI Official Synonym Full Names
myosin IXb
NCBI Official Symbol
Myo9b
UniProt Protein Name
Unconventional myosin-IXb
UniProt Synonym Protein Names
Unconventional myosin-9b
Protein Family
Unconventional myosin
UniProt Gene Name
Myo9b
NCBI Protein Information
unconventional myosin-IXb

NCBI Summary for Myo9b

displays ATP-dependent binding to actin: binds members of the rho family of GTPases; may play a role in formation of the actin cytoskeleton [RGD, Feb 2006]

UniProt Comments for Myo9b

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (). Also acts as a GTPase activator for RHOA (PubMed:7882973). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA ().
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Research Articles on Myo9b

1. data demonstrate that Myo9b and RICS repress RhoA/Rock signaling and modulate dendritic morphogenesis in cortical neurons

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Myo9b recombinant protein

 Products by Pathway  Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with Myo9b recombinant protein

 Disease Name  Pubmed Publications
 Celiac Disease Antibodies  >18 publications with Myo9b and Celiac Disease
 Disease Models, Animal Antibodies  >1 publications with Myo9b and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with Myo9b and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >1 publications with Myo9b and Congenital Abnormalities

Organs/Tissues associated with Myo9b recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with Myo9b and Brain
 Thymus Antibodies  >1 publications with Myo9b and Thymus
 Heart Antibodies  >1 publications with Myo9b and Heart
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