Human TRIB3 Recombinant Protein – Cat# MBS140961

Tribbles Pseudokinase 3 (TRIB3) Human Recombinant Protein

Name: TRIB3 Recombinant Protein; Tribbles Pseudokinase 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS140961
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140961

Introduction: Tribbles Pseudokinase 3, also known as TRIB3, is a putative protein kinase which is induced by the transcription factor NF-kappaB. In addition, TRIB3 is a negative regulator of NF-kappaB, and can as well sensitize cells to TNF- and TRAIL-induced… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tribbles Pseudokinase 3 (TRIB3), Recombinant Protein

Full Product Name

Recombinant Human Tribbles Pseudokinase 3

Product Gene Name

TRIB3 recombinant protein

Product Synonym Names

TRIB3 Human; Tribbles Pseudokinase 3 Human Recombinant; Cell Growth Regulator With EF-Hand Domain 1; Cell Growth Regulatory Gene 11 Protein; Hydrophobestin; CGR11; Cell Growth Regulator With EF Hand Domain Protein 1; Cell Growth Regulator With EF Hand Domain 1; Tribbles homolog 3

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMRA TPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCL LPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPH KHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCR FVFADRERKK LVLENLEDSC VLTGPDDSLW DKHACPAYVG PEILSSRASY SGKAADVWSL GVALFTMLAG HYPFQDSEPV LLFGKIRRGA YALPAGLSAP ARCLVRCLLR REPAERLTAT GILLHPWLRQ DPMPLAPTRS HLWEAAQVVP DGLGLDEARE EEGDREVVLY G

Host

E Coli

Form/Format

TRIB3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Molecular Weight

39,578 Da

OMIM

607898

3D Structure

ModBase 3D Structure for Q96RU7

Product Categories/Family for TRIB3 recombinant protein

Protein Kinases

Other Notes

Small volumes of TRIB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIB3 purchase

MBS140961 is a recombinant protein targeting TRIB3. Also known as Recombinant Human Tribbles Pseudokinase 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIB3. It may not necessarily be applicable to this product.

NCBI GI #

668259463

NCBI GeneID

57761

NCBI Accession #

NP_001288117.1

UniProt Primary Accession #

Q96RU7

UniProt Secondary Accession #

Q53GU4; Q53ZW7; Q6I9Y9; Q8TAI6; Q9H5M8; Q9NUD2

UniProt Related Accession #

Q96RU7

GenBank Nucleotide #

NM_001301188.1

NCBI Official Full Name

tribbles homolog 3 isoform 1

NCBI Official Synonym Full Names

tribbles pseudokinase 3

NCBI Official Symbol

TRIB3

NCBI Official Synonym Symbols

NIPK; SINK; TRB3; SKIP3; C20orf97

UniProt Protein Name

Tribbles homolog 3

UniProt Synonym Protein Names

Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B

Protein Family

Tribbles

UniProt Gene Name

TRIB3

UniProt Synonym Gene Names

C20orf97; NIPK; SKIP3; TRB3; TRB-3

UniProt Entry Name

TRIB3_HUMAN

NCBI Protein Information

tribbles homolog 3

UniProt Comments for TRIB3

TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1.

Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family

Chromosomal Location of Human Ortholog: 20p13-p12.2

Cellular Component: cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: kinase activity; mitogen-activated protein kinase kinase binding; protein binding; protein kinase binding; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity

Biological Process: cellular response to insulin stimulus; negative regulation of fat cell differentiation; negative regulation of fatty acid biosynthetic process; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of ubiquitin-protein ligase activity; regulation of MAP kinase activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TRIB3 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of AKT2 Pathway antibodies	Activation Of AKT2 Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent PI3K/Akt Signaling Pathway antibodies	CD28 Dependent PI3K/Akt Signaling Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram

Diseases associated with TRIB3 recombinant protein

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>43 publications with TRIB3 and Insulin Resistance
Cardiovascular Diseases Antibodies	>24 publications with TRIB3 and Cardiovascular Diseases
Inflammation Antibodies	>12 publications with TRIB3 and Inflammation
Necrosis Antibodies	>9 publications with TRIB3 and Necrosis
Liver Diseases Antibodies	>9 publications with TRIB3 and Liver Diseases
Breast Neoplasms Antibodies	>8 publications with TRIB3 and Breast Neoplasms
Kidney Diseases Antibodies	>7 publications with TRIB3 and Kidney Diseases
Heart Diseases Antibodies	>7 publications with TRIB3 and Heart Diseases
Nervous System Diseases Antibodies	>6 publications with TRIB3 and Nervous System Diseases
Hypertension Antibodies	>6 publications with TRIB3 and Hypertension

Organs/Tissues associated with TRIB3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>33 publications with TRIB3 and Blood
Muscle Antibodies	>28 publications with TRIB3 and Muscle
Liver Antibodies	>26 publications with TRIB3 and Liver
Vascular Antibodies	>13 publications with TRIB3 and Vascular
Kidney Antibodies	>13 publications with TRIB3 and Kidney
Bone Antibodies	>12 publications with TRIB3 and Bone
Pancreas Antibodies	>10 publications with TRIB3 and Pancreas
Lung Antibodies	>8 publications with TRIB3 and Lung
Bone Marrow Antibodies	>7 publications with TRIB3 and Bone Marrow
Brain Antibodies	>6 publications with TRIB3 and Brain