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Xylosyltransferase 2 (XYLT2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141344

Introduction: XYLT2 or Xylosyltransferase 2 is an enzyme which is expressed in ubiquitous and is part of the glycosyltransfe-rases family. XYLT2 promotes proteoglycans formation by attaching GAG chains to the substrate protein via transfer of xylose molecule… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Xylosyltransferase 2 (XYLT2), Recombinant Protein
Full Product Name
Recombinant Human Xylosyltransferase 2
Product Gene Name
XYLT2 recombinant protein
Product Synonym Names
Xylosyltransferase 2 Human Recombinant; Xylosyltransferase 2; Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II; XYLT2; XT2; XYLT2 Human
Sequence
ASGLEEDEAG EKGRQRKPRP LDPGEGSKDT DSSAGRRGST GRRHGRWRGR AESPGVPVAK VVRAVTSRQR ASRRVPPAPP PEAPGRQNLS GAAAGEALVG AAGFPPHGDT GSVEGAPQPT DNGFTPKCEI VGKDALSALA RASTKQCQQE IANVVCLHQA GSLMPKAVPR HCQLTGKMSP GIQWDESQAQ QPMDGPPVRI AYMLVVHGRA IRQLKRLLKA VYHEQHFFYI HVDKRSDYLH REVVELAQGY DNVRVTPWRM VTIWGGASLL TMYLRSMRDL LEVPGWAWDF FINLSATDYP TRTNEELVAF LSKNRDKNFL KSHGRDNSRF IKKQGLDRLF HECDSHMWRL GERQIPAGIV VDGGSDWFVL TRSFVEYVVY TDDPLVAQLR QFYTYTLLPA ESFFHTVLEN SLACETLVDN NLRVTNWNRK LGCKCQYKHI VDWCGCSPND FKPQDFLRLQ QVSRPTFFAR KFESTVNQEV LEILDFHLYG SYPPGTPALK AYWENTYDAA DGPSGLSDVM LTAYTAFARL SLHHAATAAP PMGTPLCRFE PRGLPSSVHL YFYDDHFQGY LVTQAVQPSA QGPAETLEMW LMPQGSLKLL GRSDQASRLQ SLEVGTDWDP KERLFRNFGG LLGPLDEPVA VQRWARGPNL TATVVWIDPT YVVATSYDIT VDTETEVTQY KPPLSRPLRP GPWTVRLLQF WEPLGETRFL VLPLTFNRKL PLRKDDASWL HAGPPHNEYM EQSFQGLSSI LNLPQPELAE EAAQRHTQLT GPALEAWTDR ELSSFWSVAG LCAIGPSPCP SLEPCRLTSW SSLSPDPKSE LGPVKADGRL RKLHHHHHH
Host
HEK293 Cells
Form/Format
Filtered White Lyophilized (Freeze-Dried) Powder
Filtered (0.4 um) and lyophilized in 0.05 M PBS and 0.075 M NaCl, pH 7.4.
Purity/Purification
>95.0% as determined by SDS-PAGE
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
OMIM
608125
3D Structure
ModBase 3D Structure for Q9H1B5
Solubility
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. XYLT2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Product Categories/Family for XYLT2 recombinant protein

Enzymes

Other Notes

Small volumes of XYLT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XYLT2 purchase

MBS141344 is a recombinant protein targeting XYLT2. Also known as Recombinant Human Xylosyltransferase 2. Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for XYLT2. It may not necessarily be applicable to this product.

NCBI GI #
110611246
NCBI GeneID
64132
NCBI Accession #
NP_071450.2
UniProt Primary Accession #
Q9H1B5
UniProt Related Accession #
Q9H1B5
GenBank Nucleotide #
NM_022167.3
NCBI Official Full Name
xylosyltransferase 2
NCBI Official Synonym Full Names
xylosyltransferase 2
NCBI Official Symbol
XYLT2
NCBI Official Synonym Symbols
SOS; XT2; XT-II; PXYLT2; xylT-II
UniProt Protein Name
Xylosyltransferase 2
UniProt Synonym Protein Names
Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II
Protein Family
Xylosyltransferase
UniProt Gene Name
XYLT2
UniProt Synonym Gene Names
XT2; UNQ3058/PRO9878; XT-II; XylT-II
UniProt Entry Name
XYLT2_HUMAN
NCBI Protein Information
xylosyltransferase 2

NCBI Summary for XYLT2

The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
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Research Articles on XYLT2

1. mutations in the XYLT2 gene result in a variable phenotype dominated by spinal osteoporosis, cataract, and hearing loss.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XYLT2 recombinant protein

 Reference Product  PubMed Publications
 CHPF recombinant protein  >1 publications with XYLT2 and CHPF

Pathways associated with XYLT2 recombinant protein

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram

Diseases associated with XYLT2 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with XYLT2 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with XYLT2 and Disease Models, Animal
 Neurodegenerative Diseases Antibodies  >1 publications with XYLT2 and Neurodegenerative Diseases
 Neoplasm Metastasis Antibodies  >1 publications with XYLT2 and Neoplasm Metastasis
 Autoimmune Diseases Antibodies  >1 publications with XYLT2 and Autoimmune Diseases

Organs/Tissues associated with XYLT2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with XYLT2 and Blood
 Skin Antibodies  >2 publications with XYLT2 and Skin
 Muscle Antibodies  >1 publications with XYLT2 and Muscle
 Bone Antibodies  >1 publications with XYLT2 and Bone
 Ovary Antibodies  >1 publications with XYLT2 and Ovary
 Kidney Antibodies  >1 publications with XYLT2 and Kidney
 Vascular Antibodies  >1 publications with XYLT2 and Vascular
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