Hepatocyte Growth Factor (mHGF) Mouse Recombinant Protein

Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (receptor); TK group; Met family

Cellular Component: basal plasma membrane; cell soma; cell surface; cytoplasm; dendrite; excitatory synapse; extracellular space; integral to membrane; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: ATP binding; beta-catenin binding; hepatocyte growth factor receptor activity; kinase activity; nucleotide binding; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: activation of MAPK activity; adult behavior; brain development; branching morphogenesis of a tube; cardiac muscle cell development; cardiac muscle contraction; endothelial cell morphogenesis; glucose homeostasis; hepatocyte growth factor receptor signaling pathway; liver development; muscle cell migration; muscle development; myoblast proliferation; myotube differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; peptidyl-tyrosine phosphorylation; phosphorylation; placenta development; positive chemotaxis; positive regulation of dendrite morphogenesis; positive regulation of DNA replication; positive regulation of mitosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of excitatory postsynaptic membrane potential; regulation of interleukin-6 production; regulation of synaptic transmission; skeletal muscle development; sperm motility; synaptic transmission; transmembrane receptor protein tyrosine kinase signaling pathway