Human I TAC Active Protein – Cat# MBS142041

I-TAC (I TAC) Human Active Protein

Name: I TAC Active Protein; I-TAC; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142041
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142041

Description: I-TAC Human Recombinant (Interferon-inducible T-cell alpha chemoattractant) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 8300 Dalton. The I-TAC is purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

I-TAC (I TAC), Active Protein

Full Product Name

Recombinant Human I-TAC (CXCL11)

Product Gene Name

I TAC active protein

Product Synonym Names

I TAC Human; I-TAC Human Recombinant (CXCL11); Small inducible cytokine B11; CXCL11; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Interferon-gamma-inducible protein 9; IP-9; H174; Beta-R1; chemokine (C-X-C motif) ligand 11; IP9; b-R1; SCYB11; SCYB9B; MGC102770

Sequence

FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

Host

E Coli

Form/Format

Lyophilized from a 0.2?m filtered concentrated (0.5mg/ml) solution in 20mM PB, pH 7.4, 100mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized I-TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution I-TAC should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

10,365 Da

OMIM

604852

3D Structure

ModBase 3D Structure for O14625

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized I-TAC in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by its ability to chemoattract human IL-2 activated T-Lymphocytes using a concentration range of 0.1-10.0 ng/ml.

Product Categories/Family for I TAC active protein

Chemokines; I-TAC (CXCL11)

Other Notes

Small volumes of I TAC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for I TAC purchase

MBS142041 is an active protein targeting I TAC. Also known as Recombinant Human I-TAC (CXCL11). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for I TAC. It may not necessarily be applicable to this product.

NCBI GI #

693074655

NCBI GeneID

6373

NCBI Accession #

NP_001289052.1

UniProt Primary Accession #

O14625

UniProt Secondary Accession #

Q53YA3; Q92840

UniProt Related Accession #

O14625

GenBank Nucleotide #

NM_001302123.1

NCBI Official Full Name

C-X-C motif chemokine 11 isoform 2

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 11

NCBI Official Symbol

CXCL11

NCBI Official Synonym Symbols

IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

UniProt Protein Name

C-X-C motif chemokine 11

UniProt Synonym Protein Names

Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11

Protein Family

Tail assembly protein

UniProt Gene Name

CXCL11

UniProt Synonym Gene Names

ITAC; SCYB11; SCYB9B; IP-9; I-TAC

UniProt Entry Name

CXL11_HUMAN

NCBI Protein Information

C-X-C motif chemokine 11; beta-R1; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; small-inducible cytokine B11

NCBI Summary for I TAC

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

UniProt Comments for I TAC

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; signal transduction; inflammatory response; chemotaxis; regulation of cell proliferation

Research Articles on I TAC

1. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with I TAC active protein

Reference Product	PubMed Publications
CXCL10 active protein	>461 publications with I TAC and CXCL10
CXCL9 active protein	>363 publications with I TAC and CXCL9
CXCR3 active protein	>308 publications with I TAC and CXCR3
CCL5 active protein	>87 publications with I TAC and CCL5
CXCR7 active protein	>40 publications with I TAC and CXCR7
CCR5 active protein	>38 publications with I TAC and CCR5
CXCL13 active protein	>14 publications with I TAC and CXCL13
CXCL6 active protein	>10 publications with I TAC and CXCL6
CCR3 active protein	>10 publications with I TAC and CCR3
PF4 active protein	>6 publications with I TAC and PF4

Pathways associated with I TAC active protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with I TAC active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>187 publications with I TAC and Inflammation
Necrosis Antibodies	>81 publications with I TAC and Necrosis
Lung Diseases Antibodies	>61 publications with I TAC and Lung Diseases
Disease Models, Animal Antibodies	>56 publications with I TAC and Disease Models, Animal
Liver Diseases Antibodies	>35 publications with I TAC and Liver Diseases
Cardiovascular Diseases Antibodies	>30 publications with I TAC and Cardiovascular Diseases
Fibrosis Antibodies	>28 publications with I TAC and Fibrosis
Death Antibodies	>23 publications with I TAC and Death
Kidney Diseases Antibodies	>22 publications with I TAC and Kidney Diseases
Adenocarcinoma Antibodies	>19 publications with I TAC and Adenocarcinoma

Organs/Tissues associated with I TAC active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>83 publications with I TAC and Lung
Vascular Antibodies	>77 publications with I TAC and Vascular
Skin Antibodies	>52 publications with I TAC and Skin
Liver Antibodies	>44 publications with I TAC and Liver
Muscle Antibodies	>30 publications with I TAC and Muscle
Intestine Antibodies	>27 publications with I TAC and Intestine
Bone Marrow Antibodies	>23 publications with I TAC and Bone Marrow
Mouth Antibodies	>13 publications with I TAC and Mouth
Uterus Antibodies	>9 publications with I TAC and Uterus
Connective Tissue Antibodies	>4 publications with I TAC and Connective Tissue