Terlipressin Synthetic Protein

Description: Terlipressin contains 12 amino acids Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2 and having a molecular weight of 1227.37 Dalton.

Small volumes of Terlipressin synthetic protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Terlipressin is peptide hormone which is structurally similar to lysine vasopressin with three additional glycyl residues on its N-terminus.

Functional activity of terlipressin is analogous to vasopressin’s - it is naturally occurring vasoconstrictor and its therapeutic grade is used to control low blood pressure (hypotension) and it has been found to be effective in noradrenalin (norepinephrine)-resistant cases; it’s also used for treatment of bleeding esophageal varices. Therapeutic terlipressin acts as precursor molecule which is enzymatically converted to its biologically active form - lysine vasopressin – through cleavage of its three N-terminal glycyl residues.

Antidiuretic effect of terlipressin is significantly lower than antiduretic effect of native vasopressin.

Terlipressin is dodecapeptide with molecular mass of 1227.4Da.

Peptide is provided in lyophilized form and purity of its preparation exceeds 98% as measured by RP-HPLC.

Lyophilized terlipressin is stable for up to 3 weeks at ambient temperature but recommended storage condition for this preparation is below -18°C, dessicated.