Human CRISP1 Recombinant Protein – Cat# MBS143027

Cysteine-Rich Secretory Protein 1 (CRISP1) Human Recombinant Protein

Name: CRISP1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143027
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143027

Description: The CRISP1 Protein Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 238 amino acids (Lys 22 - Lys 249) having a molecular mass of 27kDa.CRISP1 is fused to 10 amino acids His-Tag at N-terminus and purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cysteine-Rich Secretory Protein 1 (CRISP1), Recombinant Protein

Full Product Name

Recombinant Human Cysteine-Rich Secretory Protein 1

Product Gene Name

CRISP1 recombinant protein

Product Synonym Names

CRISP1 Human; Cysteine-Rich Secretory Protein 1 Human Recombinant; Cysteine-rich secretory protein 1; ARP; CRISP-1; AEGL1; Acidic epididymal glycoprotein-like 1; HSCRISP1D; HSCRISP1G; HUMARP; AEG-like protein; cysteine-rich secretory protein-1 delta

Sequence

MKHHHHHHAS KKKSAR DQFN KLVTDLPNVQ EEIVNIHNAL RRRVVPPASN MLKMSWSEEA AQNARIFSKY CDMTESNPLE RRLPNTFCGE NMHMTSYPVS WSSVIGVWYS ESTSFKHGEW TTTDDDITTD HYTQIVWATS YLIGCAIASC RQQGSPRYLY VCHYCHEGND PETKNEPYKT GVPCEACPSN CEDKLCTNPC IYYDEYFDCD IQVHYLGCNH STTILFCKAT CLCDTEIK

Host

E Coli

Form/Format

The protein was lyophilized from a 0.5mg/ml solution containing 20mM TRIS, 50mM NaCl, pH 7.5.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Molecular Weight

20,462 Da

OMIM

601193

3D Structure

ModBase 3D Structure for P54107

Solubility

It is recommended to reconstitute the lyophilized CRISP1 in sterile 18M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for CRISP1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Applications Tested/Suitable for CRISP1 recombinant protein

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of CRISP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRISP1 purchase

MBS143027 is a recombinant protein targeting CRISP1. Also known as Recombinant Human Cysteine-Rich Secretory Protein 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CRISP1. It may not necessarily be applicable to this product.

NCBI GI #

25121982

NCBI GeneID

167

NCBI Accession #

NP_001122.2

UniProt Primary Accession #

P54107

UniProt Secondary Accession #

O00698; Q13248; Q14082; Q96SF6; B5BU98

UniProt Related Accession #

P54107

GenBank Nucleotide #

NM_001131.2

NCBI Official Full Name

cysteine-rich secretory protein 1 isoform 1

NCBI Official Synonym Full Names

cysteine-rich secretory protein 1

NCBI Official Symbol

CRISP1

NCBI Official Synonym Symbols

ARP; AEGL1; HUMARP; CRISP-1; HSCRISP1D; HSCRISP1G

UniProt Protein Name

Cysteine-rich secretory protein 1

UniProt Synonym Protein Names

AEG-like protein; ARP; Acidic epididymal glycoprotein homolog

Protein Family

Cysteine-rich secretory protein

UniProt Gene Name

CRISP1

UniProt Synonym Gene Names

AEGL1; CRISP-1

UniProt Entry Name

CRIS1_HUMAN

NCBI Protein Information

cysteine-rich secretory protein 1; AEG-like protein; AEG-related protein; acidic epididymal glycoprotein homolog; acidic epididymal glycoprotein-like 1; cysteine-rich secretory protein-1 delta

NCBI Summary for CRISP1

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

UniProt Comments for CRISP1

CRISP1: May have a role in sperm-egg fusion and maturation. Belongs to the CRISP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; nucleus

Molecular Function: calcium channel regulator activity

Biological Process: fusion of sperm to egg plasma membrane; binding of sperm to zona pellucida; regulation of acrosome reaction

Research Articles on CRISP1

1. Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CRISP1 recombinant protein

Reference Product	PubMed Publications
SPINLW1 recombinant protein	>2 publications with CRISP1 and SPINLW1
GPR64 recombinant protein	>1 publications with CRISP1 and GPR64
ADAM7 recombinant protein	>1 publications with CRISP1 and ADAM7
MTDH recombinant protein	>1 publications with CRISP1 and MTDH

Diseases associated with CRISP1 recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>3 publications with CRISP1 and Disease Models, Animal
Nervous System Diseases Antibodies	>2 publications with CRISP1 and Nervous System Diseases
Pain Antibodies	>1 publications with CRISP1 and Pain
Inflammation Antibodies	>1 publications with CRISP1 and Inflammation

Organs/Tissues associated with CRISP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>12 publications with CRISP1 and Testis
Prostate Antibodies	>7 publications with CRISP1 and Prostate