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Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143263

Description: SDHAF2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (30-166 a.a) and having a molecular mass of 19kDa.SDHAF2 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Overview

Online Datasheet in PDF
Product Name
Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2), Recombinant Protein
Full Product Name
Recombinant Human Succinate Dehydrogenase Complex Assembly Factor 2
Product Gene Name
SDHAF2 recombinant protein
Product Synonym Names
SDHAF2 Human; Succinate Dehydrogenase Complex Assembly Factor 2 Human Recombinant; Succinate dehydrogenase assembly factor 2 mitochondrial; SDH assembly factor 2; Succinate dehydrogenase subunit 5; mitochondrial; hSDH5; SDHAF2; C11orf79; PGL2; SDH5
Sequence
MGSSHHH HHH SSGLVPRGSH MGSSFR RFYR GDSPTDSQKD MIEIPLPPWQ ERTDESIETK RARLLYESRK RGMLENCILL SLFAKEHLQH MTEKQLNLYD RLINEPSNDW DIYYWATEAK PAPEIFENEV MALLRDFAKN KNKEQRLRAP DLEYLFEKPR .
Host
E Coli
Form/Format
SDHAF2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
19,599 Da
OMIM
601650
3D Structure
ModBase 3D Structure for Q9NX18

Product Categories/Family for SDHAF2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of SDHAF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SDHAF2 purchase

MBS143263 is a recombinant protein targeting SDHAF2. Also known as Recombinant Human Succinate Dehydrogenase Complex Assembly Factor 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SDHAF2. It may not necessarily be applicable to this product.

NCBI GI #
8923450
NCBI GeneID
54949
NCBI Accession #
NP_060311.1
UniProt Primary Accession #
Q9NX18
UniProt Related Accession #
Q9NX18
GenBank Nucleotide #
NM_017841.2
NCBI Official Full Name
succinate dehydrogenase assembly factor 2, mitochondrial
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 2
NCBI Official Symbol
SDHAF2
NCBI Official Synonym Symbols
PGL2; SDH5; C11orf79
UniProt Protein Name
Succinate dehydrogenase assembly factor 2, mitochondrial
Protein Family
Succinate dehydrogenase assembly factor
UniProt Gene Name
SDHAF2
UniProt Entry Name
SDHF2_HUMAN
NCBI Protein Information
succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2; hSDH5; succinate dehydrogenase subunit 5, mitochondrial

NCBI Summary for SDHAF2

This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]

UniProt Comments for SDHAF2

SDH5: a subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. SDH5 is required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH) complex II. SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mutated in some cancers. Germline mutations cause hereditary paragangliomas type 2, or non-chromaffin paragangliomas type 2. Paragangliomas are rare tumors that arise from components of the neuroendocrine system.

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding

Biological Process: mitochondrial electron transport, succinate to ubiquinone; protein-FAD linkage; protein amino acid dephosphorylation

Disease: Paragangliomas 2
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Research Articles on SDHAF2

1. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SDHAF2 recombinant protein

 Reference Product  PubMed Publications
 SDHB recombinant protein  >59 publications with SDHAF2 and SDHB
 SDHD recombinant protein  >59 publications with SDHAF2 and SDHD
 SDHC recombinant protein  >56 publications with SDHAF2 and SDHC
 SDHA recombinant protein  >46 publications with SDHAF2 and SDHA
 POLE recombinant protein  >1 publications with SDHAF2 and POLE

Diseases associated with SDHAF2 recombinant protein

 Disease Name  Pubmed Publications
 Paragangliomas 2 Antibodies  >34 publications with SDHAF2 and Paragangliomas 2
 Abnormalities, Multiple Antibodies  >1 publications with SDHAF2 and Abnormalities, Multiple
 Hyperplasia Antibodies  >1 publications with SDHAF2 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with SDHAF2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >1 publications with SDHAF2 and Adenocarcinoma
 Heart Diseases Antibodies  >1 publications with SDHAF2 and Heart Diseases

Organs/Tissues associated with SDHAF2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >28 publications with SDHAF2 and Adrenal Gland
 Thyroid Antibodies  >5 publications with SDHAF2 and Thyroid
 Brain Antibodies  >4 publications with SDHAF2 and Brain
 Blood Antibodies  >3 publications with SDHAF2 and Blood
 Muscle Antibodies  >1 publications with SDHAF2 and Muscle
 Heart Antibodies  >1 publications with SDHAF2 and Heart
 Kidney Antibodies  >1 publications with SDHAF2 and Kidney
 Bone Antibodies  >1 publications with SDHAF2 and Bone
 Vascular Antibodies  >1 publications with SDHAF2 and Vascular
 Liver Antibodies  >1 publications with SDHAF2 and Liver
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