Casein Kinase 2 Beta (CK2b) Human Recombinant Protein

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; plasma membrane; protein kinase CK2 complex; PcG protein complex; cytosol; nucleus

Molecular Function: identical protein binding; protein domain specific binding; protein serine/threonine kinase activity; protein binding; metal ion binding; protein kinase regulator activity; transcription factor binding; receptor binding

Biological Process: negative regulation of cell proliferation; axon guidance; positive regulation of activin receptor signaling pathway; cellular protein complex assembly; Wnt receptor signaling pathway; regulation of DNA binding; adiponectin-mediated signaling pathway; mitotic cell cycle; negative regulation of blood vessel endothelial cell migration; regulation of protein kinase activity; signal transduction; protein amino acid phosphorylation