Baculovirus CSF1 Active Protein – Cat# MBS206571

CSF1 Baculovirus Active Protein

Name: CSF1 Active Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206571
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206571

CSF1, also known as macrophage colony-stimulating factor 1, is a hematopoietic growth factor that is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. It is a four alpha-helical bundle cytokine and… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CSF1, Active Protein

Full Product Name

CSF1, 33-255aa, Human, His-tag, Baculovirus (Bioactivity Validated)

Product Gene Name

CSF1 active protein

Product Synonym Names

Macrophage colony-stimulating factor 1; CSF1; M-CSF; MCSF; Lanimostim

Sequence

EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQD VVTKPDCNCL YPKAIPSSDP ASVSPHQPLA PSMAPVAGLT WEDSEGTEGS SLLPGEQPLH TVDPGSAKQR PPRLEHHHHH H

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

26.1kDa (231aa) 28-40KDa (SDS-PAGE under reducing conditions.)

3D Structure

ModBase 3D Structure for P09603

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Biological Activity

Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cell. The ED50 for this effect is less or equal to 3 ng/ml.

Product Categories/Family for CSF1 active protein

Immunology

Applications Tested/Suitable for CSF1 active protein

SDS-PAGE

Product References and Citations for CSF1 active protein

Chitu V., et al. (2006) Curr Opin Immunol. 18 (1):39-48.; Eda H., et al. (2010) Cytokine. 52 (3):215-220.; Tian F., et al. (2013) Oncol. Res. 20 (8):341-350.

Other Notes

Small volumes of CSF1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSF1 purchase

MBS206571 is an active protein targeting CSF1. Also known as CSF1, 33-255aa, Human, His-tag, Baculovirus (Bioactivity Validated). Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CSF1. It may not necessarily be applicable to this product.

NCBI GI #

27262661

NCBI GeneID

1435

NCBI Accession #

NP_000748

UniProt Primary Accession #

P09603

UniProt Secondary Accession #

Q13130; Q14086; Q14806; Q5VVF3; Q5VVF4; Q9UQR8; A8K6J5

UniProt Related Accession #

P09603

GenBank Nucleotide #

NM_000757.5

NCBI Official Full Name

macrophage colony-stimulating factor 1 isoform a

NCBI Official Synonym Full Names

colony stimulating factor 1

NCBI Official Symbol

CSF1

NCBI Official Synonym Symbols

MCSF; CSF-1

UniProt Protein Name

Macrophage colony-stimulating factor 1

UniProt Synonym Protein Names

Lanimostim

Protein Family

Macrophage colony-stimulating factor

UniProt Gene Name

CSF1

UniProt Synonym Gene Names

CSF-1; M-CSF; MCSF

NCBI Protein Information

macrophage colony-stimulating factor 1

NCBI Summary for CSF1

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

UniProt Comments for CSF1

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Research Articles on CSF1

1. miR-1207-5p and CSF1 expression levels and their relationship with lung cancer survival and metastasis status were assayed by means of a lung cancer tissue microarray.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CSF1 active protein

Reference Product	PubMed Publications
CSF1R active protein	>94 publications with CSF1 and CSF1R
TNF active protein	>34 publications with CSF1 and TNF
KIT active protein	>10 publications with CSF1 and KIT
EGFR active protein	>8 publications with CSF1 and EGFR
ITGB3 active protein	>3 publications with CSF1 and ITGB3
HRAS active protein	>1 publications with CSF1 and HRAS

Pathways associated with CSF1 active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Development Of Pulmonary Dendritic Cells And Macrophage Subsets Pathway antibodies	Development Of Pulmonary Dendritic Cells And Macrophage Subsets Pathway Diagram
Differentiation Pathway antibodies	Differentiation Pathway Diagram
Folate Metabolism Pathway antibodies	Folate Metabolism Pathway Diagram
Hematopoietic Stem Cell Differentiation Pathway antibodies	Hematopoietic Stem Cell Differentiation Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with CSF1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>72 publications with CSF1 and Inflammation
Carcinoma Antibodies	>33 publications with CSF1 and Carcinoma
Breast Neoplasms Antibodies	>31 publications with CSF1 and Breast Neoplasms
Necrosis Antibodies	>28 publications with CSF1 and Necrosis
Lung Neoplasms Antibodies	>19 publications with CSF1 and Lung Neoplasms
Adenocarcinoma Antibodies	>17 publications with CSF1 and Adenocarcinoma
Death Antibodies	>15 publications with CSF1 and Death
Lung Diseases Antibodies	>15 publications with CSF1 and Lung Diseases
Liver Diseases Antibodies	>13 publications with CSF1 and Liver Diseases
Neoplasms, Experimental Antibodies	>12 publications with CSF1 and Neoplasms, Experimental

Organs/Tissues associated with CSF1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>117 publications with CSF1 and Blood
Bone Antibodies	>88 publications with CSF1 and Bone
Lung Antibodies	>39 publications with CSF1 and Lung
Liver Antibodies	>34 publications with CSF1 and Liver
Brain Antibodies	>28 publications with CSF1 and Brain
Kidney Antibodies	>18 publications with CSF1 and Kidney
Nerve Antibodies	>17 publications with CSF1 and Nerve
Connective Tissue Antibodies	>16 publications with CSF1 and Connective Tissue
Lymph Node Antibodies	>14 publications with CSF1 and Lymph Node
Muscle Antibodies	>14 publications with CSF1 and Muscle