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Glutathione S-Transferase Omega 1 (GSTO1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143628

Description: GSTO1 Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 241 amino acids fragment (1-241) having a Mw of 32.1 kDa.GSTO1 is fused with an amino-terminal hexahistidine tag having a total Mw of 36kDa and… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Glutathione S-Transferase Omega 1 (GSTO1), Recombinant Protein
Full Product Name
Recombinant Human Glutathione S-Transferase Omega 1
Product Gene Name
GSTO1 recombinant protein
Product Synonym Names
GSTO1 Human; Glutathione S-Transferase Omega 1 Human Recombinant; Glutathione S-transferase omega-1; GSTO 1-1; GSTO1; GSTTLP28; P28; DKFZp686H13163
Host
E Coli
Form/Format
GSTO1 protein is supplied in 20 mM Tris pH 8.0 and 50% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
Molecular Weight
24,796 Da
OMIM
605482
3D Structure
ModBase 3D Structure for P78417

Product Categories/Family for GSTO1 recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of GSTO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSTO1 purchase

MBS143628 is a recombinant protein targeting GSTO1. Also known as Recombinant Human Glutathione S-Transferase Omega 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GSTO1. It may not necessarily be applicable to this product.

NCBI GI #
300360532
NCBI GeneID
9446
NCBI Accession #
NP_001177931.1
UniProt Primary Accession #
P78417
UniProt Secondary Accession #
Q5TA03; Q7Z3T2; D3DRA3; F5H7H0
UniProt Related Accession #
P78417
GenBank Nucleotide #
NM_001191002.1
NCBI Official Full Name
glutathione S-transferase omega-1 isoform 2
NCBI Official Synonym Full Names
glutathione S-transferase omega 1
NCBI Official Symbol
GSTO1
NCBI Official Synonym Symbols
P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
UniProt Protein Name
Glutathione S-transferase omega-1
UniProt Synonym Protein Names
Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1); Monomethylarsonic acid reductase (EC:1.20.4.2); MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R
Protein Family
Glutathione S-transferase
UniProt Gene Name
GSTO1
UniProt Synonym Gene Names
GSTTLP28; GSTO-1; GSTO 1-1; MMA(V) reductase; SPG-R
UniProt Entry Name
GSTO1_HUMAN
NCBI Protein Information
glutathione S-transferase omega-1; GSTO-1; MMA(V) reductase; S-(Phenacyl)glutathione reductase; epididymis secretory protein Li 21; glutathione S-transferase omega 1-1; glutathione-S-transferase like; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase

NCBI Summary for GSTO1

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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UniProt Comments for GSTO1

GSTO1: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family.

Protein type: Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.8.5.1; Transferase; EC 1.20.4.2; EC 2.5.1.18

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; glutathione transferase activity; glutathione dehydrogenase (ascorbate) activity; methylarsonate reductase activity; oxidoreductase activity

Biological Process: positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; xenobiotic metabolic process; L-ascorbic acid metabolic process; xenobiotic catabolic process
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Research Articles on GSTO1

1. GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GSTO1 recombinant protein

 Reference Product  PubMed Publications
 GSTP1 recombinant protein  >24 publications with GSTO1 and GSTP1
 GSTM1 recombinant protein  >21 publications with GSTO1 and GSTM1
 AS3MT recombinant protein  >16 publications with GSTO1 and AS3MT
 GSTA1 recombinant protein  >14 publications with GSTO1 and GSTA1
 GSTM2 recombinant protein  >9 publications with GSTO1 and GSTM2
 GSTM3 recombinant protein  >8 publications with GSTO1 and GSTM3
 GSTA4 recombinant protein  >5 publications with GSTO1 and GSTA4
 GSTM5 recombinant protein  >3 publications with GSTO1 and GSTM5
 GSTK1 recombinant protein  >3 publications with GSTO1 and GSTK1
 GSTT2B recombinant protein  >1 publications with GSTO1 and GSTT2B

Pathways associated with GSTO1 recombinant protein

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram

Diseases associated with GSTO1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >24 publications with GSTO1 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >19 publications with GSTO1 and Neurodegenerative Diseases
 Inflammation Antibodies  >11 publications with GSTO1 and Inflammation
 Skin Diseases Antibodies  >9 publications with GSTO1 and Skin Diseases
 Breast Neoplasms Antibodies  >9 publications with GSTO1 and Breast Neoplasms
 Poisoning Antibodies  >8 publications with GSTO1 and Poisoning
 Neurotoxicity Syndromes Antibodies  >7 publications with GSTO1 and Neurotoxicity Syndromes
 Leukemia Antibodies  >6 publications with GSTO1 and Leukemia
 Lung Diseases Antibodies  >6 publications with GSTO1 and Lung Diseases
 Liver Diseases Antibodies  >4 publications with GSTO1 and Liver Diseases

Organs/Tissues associated with GSTO1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with GSTO1 and Liver
 Blood Antibodies  >19 publications with GSTO1 and Blood
 Brain Antibodies  >10 publications with GSTO1 and Brain
 Bladder Antibodies  >7 publications with GSTO1 and Bladder
 Lung Antibodies  >6 publications with GSTO1 and Lung
 Heart Antibodies  >6 publications with GSTO1 and Heart
 Vascular Antibodies  >5 publications with GSTO1 and Vascular
 Muscle Antibodies  >5 publications with GSTO1 and Muscle
 Kidney Antibodies  >5 publications with GSTO1 and Kidney
 Prostate Antibodies  >4 publications with GSTO1 and Prostate
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