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Proline-Rich Protein 5 (PRR5) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1436559

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. Rare read-through transcripts, containing exons… More details

$1120 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Proline-rich protein 5 (Prr5), Recombinant Protein
Full Product Name
Recombinant Mouse Proline-rich protein 5 (Prr5)
Product Gene Name
Prr5 recombinant protein
Product Synonym Gene Name
Prr5
Sequence
MRTLRRLKFM SSPSLSDLGK REPGAAGTDE RGTQQRRACA NATWNSIHNG VIAVFQRKGL PDQELFILNE GVRQLLKTEL GSFFTEYLQN QLLTKGMVIL RDKIRFYEGQ KLLDSLAETW DFFFSDVLPT LQAIFYPVQG KEPSVRQLAL LHFRNTITLS VKLEDALARS HARVPPAIAQ MLLVLQGVHE SRGVTEDYLR LETLIQKVVS PYLGTYGLYS NEGPCTHSCI LEKRFLRRSR SGDILAKNPV VRSKSYNTPL LNPVAEHEAE GTAASGTSIR RHSVSEMTSC PEPQGFVDTP GQGPSGTFRS SPTPHSGPCP SRLYPPAHSP EQGPGHGSPS TSSPETLVDQ ILESADSDSE GIFIDFGRGS RSSVSDFEAP GGRPSVV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
41,321 Da
Sequence Positions
1-387, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q812A5
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Prr5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Prr5 purchase

MBS1436559 is a recombinant protein targeting Prr5. Also known as Recombinant Mouse Proline-rich protein 5 (Prr5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Prr5. It may not necessarily be applicable to this product.

NCBI GI #
1090864021
NCBI GeneID
109270
NCBI Accession #
NP_001333591.1
UniProt Primary Accession #
Q812A5
UniProt Secondary Accession #
Q5EAK2; Q8BIE7; Q8BIK1; Q8R1A0
UniProt Related Accession #
Q812A5
GenBank Nucleotide #
NM_001346662.1
NCBI Official Full Name
proline-rich protein 5 isoform 2
NCBI Official Synonym Full Names
proline rich 5 (renal)
NCBI Official Symbol
Prr5
NCBI Official Synonym Symbols
C78947; Arhgap8; Protor1; AU043908; Protor-1; C030017C09Rik
UniProt Protein Name
Proline-rich protein 5
UniProt Synonym Protein Names
Protein observed with Rictor-1; Protor-1
Protein Family
Proline-rich protein
UniProt Gene Name
Prr5
UniProt Synonym Gene Names
Protor-1
NCBI Protein Information
proline-rich protein 5

UniProt Comments for Prr5

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Prr5 recombinant protein

 Disease Name  Pubmed Publications
 Intestinal Neoplasms Antibodies  >2 publications with Prr5 and Intestinal Neoplasms
 Breast Neoplasms Antibodies  >2 publications with Prr5 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with Prr5 and Necrosis
 Prostatic Neoplasms Antibodies  >1 publications with Prr5 and Prostatic Neoplasms

Organs/Tissues associated with Prr5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with Prr5 and Kidney
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