Human AKR1B10 Recombinant Protein – Cat# MBS143732

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) Human Recombinant Protein

Name: AKR1B10 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143732
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143732

Description: AKR1B10 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 316 amino acids (1-316 a.a) and having a molecular mass of 36 kDa. The AKR1B10 is purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10), Recombinant Protein

Full Product Name

Recombinant Human Aldo-Keto Reductase Family 1 Member B10

Product Gene Name

AKR1B10 recombinant protein

Product Synonym Names

AKR1B10 Human; Aldo-Keto Reductase Family 1 Member B10 Human Recombinant; HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; MGC14103; AKR1B10; Aldo-keto reductase family 1 member B10; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase

Sequence

MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY

Host

E Coli

Form/Format

The AKR1B10 solution contains 20mM Tris-HCl pH-8 and 10% glycerol.
Sterile Filtered clear colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

AKR1B10 Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.

Molecular Weight

36,020 Da

OMIM

604707

3D Structure

ModBase 3D Structure for O60218

Product Categories/Family for AKR1B10 recombinant protein

Enzymes; Reductase

Other Notes

Small volumes of AKR1B10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1B10 purchase

MBS143732 is a recombinant protein targeting AKR1B10. Also known as Recombinant Human Aldo-Keto Reductase Family 1 Member B10. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1B10. It may not necessarily be applicable to this product.

NCBI GI #

223468663

NCBI GeneID

57016

NCBI Accession #

NP_064695.3

UniProt Primary Accession #

O60218

UniProt Secondary Accession #

O75890; Q6FHF3; Q8IWZ1; A4D1P1

UniProt Related Accession #

O60218

GenBank Nucleotide #

NM_020299.4

NCBI Official Full Name

aldo-keto reductase family 1 member B10

NCBI Official Synonym Full Names

aldo-keto reductase family 1, member B10 (aldose reductase)

NCBI Official Symbol

AKR1B10

NCBI Official Synonym Symbols

HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12

UniProt Protein Name

Aldo-keto reductase family 1 member B10

UniProt Synonym Protein Names

ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase

Protein Family

Aldo-keto reductase family

UniProt Gene Name

AKR1B10

UniProt Synonym Gene Names

AKR1B11; ARP; hARP; SI reductase

UniProt Entry Name

AK1BA_HUMAN

NCBI Protein Information

aldo-keto reductase family 1 member B10; ARP; SI reductase; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like 1; aldose reductase-like peptide; aldose reductase-related protein; hARP; small intestine reductase

NCBI Summary for AKR1B10

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

UniProt Comments for AKR1B10

AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.21; Carbohydrate Metabolism - butanoate; Oxidoreductase; Lipid Metabolism - linoleic acid; EC 1.1.1.-

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: lysosome; cytosol

Molecular Function: protein binding; aldo-keto reductase activity; indanol dehydrogenase activity; geranylgeranyl reductase activity; retinal dehydrogenase activity

Biological Process: steroid metabolic process; phototransduction, visible light; digestion; aldehyde metabolic process; farnesol catabolic process; retinoid metabolic process

Research Articles on AKR1B10

1. AKR1B10 may have an important role in the development and progression of diabetic nephropathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKR1B10 recombinant protein

Reference Product	PubMed Publications
ALDH3A1 recombinant protein	>5 publications with AKR1B10 and ALDH3A1
GPX2 recombinant protein	>3 publications with AKR1B10 and GPX2
CBR1 recombinant protein	>2 publications with AKR1B10 and CBR1
CBR3 recombinant protein	>2 publications with AKR1B10 and CBR3
EGF recombinant protein	>1 publications with AKR1B10 and EGF

Pathways associated with AKR1B10 recombinant protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With Visual Transduction Pathway antibodies	Diseases Associated With Visual Transduction Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Galactose Metabolism Pathway antibodies	Galactose Metabolism Pathway Diagram
Galactose Metabolism Pathway antibodies	Galactose Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Pentose And Glucuronate Interconversions Pathway antibodies	Pentose And Glucuronate Interconversions Pathway Diagram

Diseases associated with AKR1B10 recombinant protein

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>24 publications with AKR1B10 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>22 publications with AKR1B10 and Liver Neoplasms
Liver Diseases Antibodies	>20 publications with AKR1B10 and Liver Diseases
Lung Neoplasms Antibodies	>20 publications with AKR1B10 and Lung Neoplasms
Breast Neoplasms Antibodies	>9 publications with AKR1B10 and Breast Neoplasms
Colorectal Neoplasms Antibodies	>8 publications with AKR1B10 and Colorectal Neoplasms
Inflammation Antibodies	>5 publications with AKR1B10 and Inflammation
Neoplasm Metastasis Antibodies	>5 publications with AKR1B10 and Neoplasm Metastasis
Liver Cirrhosis Antibodies	>5 publications with AKR1B10 and Liver Cirrhosis
Fatty Liver Antibodies	>5 publications with AKR1B10 and Fatty Liver

Organs/Tissues associated with AKR1B10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>39 publications with AKR1B10 and Liver
Lung Antibodies	>38 publications with AKR1B10 and Lung
Intestine Antibodies	>9 publications with AKR1B10 and Intestine
Stomach Antibodies	>5 publications with AKR1B10 and Stomach
Uterus Antibodies	>4 publications with AKR1B10 and Uterus
Kidney Antibodies	>4 publications with AKR1B10 and Kidney
Eye Antibodies	>3 publications with AKR1B10 and Eye
Esophagus Antibodies	>2 publications with AKR1B10 and Esophagus
Skin Antibodies	>2 publications with AKR1B10 and Skin
Brain Antibodies	>2 publications with AKR1B10 and Brain