Human SERPINA3 Recombinant Protein – Cat# MBS143762

Alpha-1 Antichymotrypsin (SERPINA3) Human Recombinant Protein

Name: SERPINA3 Recombinant Protein; Alpha-1 Antichymotrypsin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143762
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143762

Description: SERPINA3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 421 amino acids (24-423 a.a.) and having a molecular mass of 47.6 kDa.The SERPINA3 is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Alpha-1 AntiChymotrypsin (SERPINA3), Recombinant Protein

Full Product Name

Recombinant Human Alpha-1 AntiChymotrypsin

Product Gene Name

SERPINA3 recombinant protein

Product Synonym Names

SERPINA3 Human; Alpha-1 AntiChymotrypsin Human Recombinant; Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; SERPINA3; AACT; A1ACT; GIG24; GIG25; MGC88254

Sequence

MGSSHHH HHH SSGLVPRGSH MHPNSP LDEE NLTQENQDRG THVDLGLASA NVDFAFSLYK QLVLKAPDKN VIFSPLSIST ALAFLSLGAH NTTLTEILKG LKFNLTETSE AEIHQSFQHL LRTLNQSSDE LQLSMGNAMF VKEQLSLLDR FTEDAKRLYG SEAFATDFQD SAAAKKLIND YVKNGTRGKI TDLIKDLDSQ TMMVLVNYIF FKAKWEMPFD PQDTHQSRFY LSKKKWVMVP MMSLHHLTIP YFRDEELSCT VVELKYTGNA SALFILPDQD KMEEVEAMLL PETLKRWRDS LEFREIGELY LPKFSISRDY NLNDILLQLG IEEAFTSKAD LSGITGARNL AVSQVVHKAV LDVFEEGTEA SAATAVKITL LSALVETRTI VRFNRPFLMI IVPTDTQNIF FMSKVTNPKQ A

Host

E Coli

Form/Format

The SERPINA3 solution contains 20mM Tris-HCl buffer pH-8, 1mM DTT, and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

10,717 Da

OMIM

107280

3D Structure

ModBase 3D Structure for P01011

Product Categories/Family for SERPINA3 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Serpin

Other Notes

Small volumes of SERPINA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINA3 purchase

MBS143762 is a recombinant protein targeting SERPINA3. Also known as Recombinant Human Alpha-1 AntiChymotrypsin. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.

NCBI GI #

50659080

NCBI GeneID

NCBI Accession #

NP_001076.2

UniProt Primary Accession #

P01011

UniProt Secondary Accession #

Q13703; Q2TU87; Q2TU88; Q59GP9; Q6LBY8; Q6LDT7; Q6NSC9; Q8N177; Q96DW8; Q9UC47; B3KVQ7

UniProt Related Accession #

P01011

GenBank Nucleotide #

NM_001085.4

NCBI Official Full Name

alpha-1-antichymotrypsin

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

NCBI Official Symbol

SERPINA3

NCBI Official Synonym Symbols

ACT; AACT; GIG24; GIG25

UniProt Protein Name

Alpha-1-antichymotrypsin

UniProt Synonym Protein Names

Cell growth-inhibiting gene 24/25 protein; Serpin A3Alpha-1-antichymotrypsin His-Pro-less

Protein Family

Alpha-1-antichymotrypsin

UniProt Gene Name

SERPINA3

UniProt Synonym Gene Names

AACT; ACT

UniProt Entry Name

AACT_HUMAN

NCBI Protein Information

alpha-1-antichymotrypsin; cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin A3

NCBI Summary for SERPINA3

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPINA3

SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response

Research Articles on SERPINA3

1. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SERPINA3 recombinant protein

Products by Pathway	Pathway Diagram
Selenium Pathway antibodies	Selenium Pathway Diagram

Diseases associated with SERPINA3 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>16 publications with SERPINA3 and Inflammation
Cardiovascular Diseases Antibodies	>14 publications with SERPINA3 and Cardiovascular Diseases
Mental Disorders Antibodies	>8 publications with SERPINA3 and Mental Disorders
Breast Neoplasms Antibodies	>5 publications with SERPINA3 and Breast Neoplasms
Heart Diseases Antibodies	>4 publications with SERPINA3 and Heart Diseases
Necrosis Antibodies	>4 publications with SERPINA3 and Necrosis
Hypertension Antibodies	>4 publications with SERPINA3 and Hypertension
Liver Diseases Antibodies	>4 publications with SERPINA3 and Liver Diseases
Heart Failure Antibodies	>3 publications with SERPINA3 and Heart Failure
Seizures Antibodies	>1 publications with SERPINA3 and Seizures

Organs/Tissues associated with SERPINA3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with SERPINA3 and Blood
Brain Antibodies	>12 publications with SERPINA3 and Brain
Liver Antibodies	>7 publications with SERPINA3 and Liver
Muscle Antibodies	>6 publications with SERPINA3 and Muscle
Lung Antibodies	>4 publications with SERPINA3 and Lung
Uterus Antibodies	>4 publications with SERPINA3 and Uterus
Placenta Antibodies	>3 publications with SERPINA3 and Placenta
Heart Antibodies	>3 publications with SERPINA3 and Heart
Skin Antibodies	>2 publications with SERPINA3 and Skin
Eye Antibodies	>2 publications with SERPINA3 and Eye