Mouse mENA 78 Active Protein – Cat# MBS143795

Epithelial Neutrophil-Activating Protein 78 (mENA 78) Mouse Active Protein

Name: mENA 78 Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143795
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143795

Description: Epithelial Neutrophil-Activating Protein 78 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 93 amino acids and having a molecular mass of 9.8kDa. The CXCL5 is purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Epithelial Neutrophil-Activating Protein 78 (mENA 78), Active Protein

Full Product Name

Recombinant Mouse Epithelial Neutrophil-Activating Protein 78 (CXCL5)

Product Gene Name

mENA 78 active protein

Product Synonym Names

ENA 78 Mouse; Epithelial Neutrophil-Activating Protein 78 Mouse Recombinant (CXCL5); C-X-C motif chemokine 5; Small-inducible cytokine B5; Cytokine LIX; Cxcl5; Scyb5; LIX; GCP-2; Scyb6; ENA-78; AMCF-II

Sequence

APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered concentrated (1.0mg/ml) solution in 20mM sodium phosphate buffer, pH 7.4 & 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized ENA-78 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

14,235 Da

3D Structure

ModBase 3D Structure for P50228

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized ENA-78 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Product Categories/Family for mENA 78 active protein

Chemokines; ENA 78

Other Notes

Small volumes of mENA 78 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mENA 78 purchase

MBS143795 is an active protein targeting mENA 78. Also known as Recombinant Mouse Epithelial Neutrophil-Activating Protein 78 (CXCL5). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mENA 78. It may not necessarily be applicable to this product.

NCBI GI #

114842398

NCBI GeneID

20311

NCBI Accession #

NP_033167.2

UniProt Primary Accession #

P50228

UniProt Secondary Accession #

Q8K3I3

UniProt Related Accession #

P50228

GenBank Nucleotide #

NM_009141.3

NCBI Official Full Name

C-X-C motif chemokine 5

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 5

NCBI Official Symbol

Cxcl5

NCBI Official Synonym Symbols

LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II

UniProt Protein Name

C-X-C motif chemokine 5

UniProt Synonym Protein Names

Cytokine LIX; Small-inducible cytokine B5Cleaved into the following 2 chains:GCP-2(1-78); GCP-2(9-78)

UniProt Gene Name

Cxcl5

UniProt Synonym Gene Names

Scyb5

UniProt Entry Name

CXCL5_MOUSE

NCBI Protein Information

C-X-C motif chemokine 5; cytokine LIX; granulocyte chemotactic protein-2; small inducible cytokine B subfamily, member 5; small inducible cytokine subfamily B, member 15; small-inducible cytokine B5

NCBI Summary for mENA 78

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]

UniProt Comments for mENA 78

CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; organ regeneration; cytokine production; positive regulation of JAK-STAT cascade; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; chemotaxis; inflammatory response; regulation of chemokine production; leukocyte homeostasis; regulation of cell proliferation

Research Articles on mENA 78

1. Since adaptive villus growth occurs despite impaired CXCL5 expression and enhanced angiogenesis, this suggests that the growth of new blood vessels is not needed for resection-induced mucosal surface area expansion following massive SBR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with mENA 78 active protein

Reference Product	PubMed Publications
Cxcl1 active protein	>231 publications with mENA 78 and Cxcl1
Cxcr2 active protein	>88 publications with mENA 78 and Cxcr2
Ccl5 active protein	>74 publications with mENA 78 and Ccl5
Ccl20 active protein	>42 publications with mENA 78 and Ccl20
Cxcl12 active protein	>33 publications with mENA 78 and Cxcl12
Cxcr1 active protein	>26 publications with mENA 78 and Cxcr1
Cxcr3 active protein	>15 publications with mENA 78 and Cxcr3
Cxcl16 active protein	>11 publications with mENA 78 and Cxcl16
Ccr1 active protein	>8 publications with mENA 78 and Ccr1
Ccr2 active protein	>6 publications with mENA 78 and Ccr2

Pathways associated with mENA 78 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with mENA 78 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>240 publications with mENA 78 and Inflammation
Respiratory Tract Diseases Antibodies	>102 publications with mENA 78 and Respiratory Tract Diseases
Necrosis Antibodies	>102 publications with mENA 78 and Necrosis
Lung Diseases Antibodies	>92 publications with mENA 78 and Lung Diseases
Disease Models, Animal Antibodies	>65 publications with mENA 78 and Disease Models, Animal
Carcinoma Antibodies	>60 publications with mENA 78 and Carcinoma
Cardiovascular Diseases Antibodies	>45 publications with mENA 78 and Cardiovascular Diseases
Fibrosis Antibodies	>28 publications with mENA 78 and Fibrosis
Lung Neoplasms Antibodies	>27 publications with mENA 78 and Lung Neoplasms
Pneumonia Antibodies	>27 publications with mENA 78 and Pneumonia

Organs/Tissues associated with mENA 78 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>40 publications with mENA 78 and Liver
Intestine Antibodies	>34 publications with mENA 78 and Intestine
Eye Antibodies	>17 publications with mENA 78 and Eye
Connective Tissue Antibodies	>16 publications with mENA 78 and Connective Tissue
Embryonic Tissue Antibodies	>14 publications with mENA 78 and Embryonic Tissue
Spleen Antibodies	>9 publications with mENA 78 and Spleen
Adipose Tissue Antibodies	>8 publications with mENA 78 and Adipose Tissue
Pancreas Antibodies	>6 publications with mENA 78 and Pancreas
Mammary Gland Antibodies	>3 publications with mENA 78 and Mammary Gland
Vagina Antibodies	>2 publications with mENA 78 and Vagina