Human PRDX6 Active Protein – Cat# MBS143893

Peroxiredoxin-6 (PRDX6) Human Active Protein

Name: PRDX6 Active Protein; Peroxiredoxin-6; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143893
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143893

Description: Peroxiredoxin- 6 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 244 amino acids (1-224 a.a.) and having a molecular mass of 27.1kDa.The… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Peroxiredoxin-6 (PRDX6), Active Protein

Full Product Name

Recombinant Human Peroxiredoxin-6

Product Gene Name

PRDX6 active protein

Product Synonym Names

PRDX6 Human; Peroxiredoxin-6 Human Recombinant; Peroxiredoxin-6; Antioxidant protein 2; 1-Cys peroxiredoxin; Acidic calcium-independent phospholipase A2; Non-selenium glutathione peroxidase; 24 kDa protein; Liver 2D page spot 40; Red blood cells page spot 12; 1-Cys PRX; aiPLA2; NSGPx; PRDX6; AOP2; KIAA0106; PRX; p29; 1-Cys; MGC46173

Sequence

MGSSHHH HHH SSGLVPRGSH MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP

Host

E Coli

Form/Format

The Peroxiredoxin-6 solution contains 20mM Tris-HCl buffer (pH8.0) and 20% Glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

25,035 Da

OMIM

602316

3D Structure

ModBase 3D Structure for P30041

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The specific activity was found to be approximately 95-120 pmole/min/ ug. The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX6 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25 degree C for 1 minute.

Product Categories/Family for PRDX6 active protein

Enzymes; Peroxiredoxin

Other Notes

Small volumes of PRDX6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX6 purchase

MBS143893 is an active protein targeting PRDX6. Also known as Recombinant Human Peroxiredoxin-6. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.

NCBI GI #

4758638

NCBI GeneID

9588

NCBI Accession #

NP_004896.1

UniProt Primary Accession #

P30041

UniProt Secondary Accession #

P32077; Q5TAH4; Q5ZEZ8; A8JZY7

UniProt Related Accession #

P30041

GenBank Nucleotide #

NM_004905.2

NCBI Official Full Name

peroxiredoxin-6

NCBI Official Synonym Full Names

peroxiredoxin 6

NCBI Official Symbol

PRDX6

NCBI Official Synonym Symbols

PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m

UniProt Protein Name

Peroxiredoxin-6

UniProt Synonym Protein Names

1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.-); aiPLA2; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase (EC:1.11.1.9); NSGPx; Red blood cells page spot 12

Protein Family

Peroxiredoxin

UniProt Gene Name

PRDX6

UniProt Synonym Gene Names

AOP2; KIAA0106; 1-Cys PRX; aiPLA2; NSGPx

UniProt Entry Name

PRDX6_HUMAN

NCBI Protein Information

peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 24 kDa protein; acidic calcium-independent phospholipase A2; antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; liver 2D page spot 40; non-selenium glutathione peroxidase; red blood cells page spot 12

NCBI Summary for PRDX6

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

UniProt Comments for PRDX6

PRDX6: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily.

Protein type: EC 1.11.1.9; Oxidoreductase; Energy Metabolism - methane; Amino Acid Metabolism - phenylalanine; Phospholipase; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function: antioxidant activity; phospholipase A2 activity; protein binding; peroxiredoxin activity; glutathione peroxidase activity

Biological Process: response to reactive oxygen species; hydrogen peroxide catabolic process; phospholipid catabolic process; response to oxidative stress

Research Articles on PRDX6

1. our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRDX6 active protein

Reference Product	PubMed Publications
CAT active protein	>6 publications with PRDX6 and CAT
TXN active protein	>2 publications with PRDX6 and TXN
TAT active protein	>2 publications with PRDX6 and TAT
PSIP1 active protein	>1 publications with PRDX6 and PSIP1
PAH active protein	>1 publications with PRDX6 and PAH

Pathways associated with PRDX6 active protein

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Phenylalanine Metabolism Pathway antibodies	Phenylalanine Metabolism Pathway Diagram
Phenylalanine Metabolism Pathway antibodies	Phenylalanine Metabolism Pathway Diagram

Diseases associated with PRDX6 active protein

Disease Name	Pubmed Publications
Death Antibodies	>23 publications with PRDX6 and Death
Lung Diseases Antibodies	>17 publications with PRDX6 and Lung Diseases
Nervous System Diseases Antibodies	>17 publications with PRDX6 and Nervous System Diseases
Disease Models, Animal Antibodies	>17 publications with PRDX6 and Disease Models, Animal
Inflammation Antibodies	>16 publications with PRDX6 and Inflammation
Necrosis Antibodies	>10 publications with PRDX6 and Necrosis
Cardiovascular Diseases Antibodies	>9 publications with PRDX6 and Cardiovascular Diseases
Atherosclerosis Antibodies	>8 publications with PRDX6 and Atherosclerosis
Liver Diseases Antibodies	>7 publications with PRDX6 and Liver Diseases
Lung Neoplasms Antibodies	>6 publications with PRDX6 and Lung Neoplasms

Organs/Tissues associated with PRDX6 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>48 publications with PRDX6 and Lung
Blood Antibodies	>29 publications with PRDX6 and Blood
Liver Antibodies	>28 publications with PRDX6 and Liver
Brain Antibodies	>27 publications with PRDX6 and Brain
Eye Antibodies	>16 publications with PRDX6 and Eye
Vascular Antibodies	>16 publications with PRDX6 and Vascular
Kidney Antibodies	>11 publications with PRDX6 and Kidney
Muscle Antibodies	>10 publications with PRDX6 and Muscle
Nerve Antibodies	>8 publications with PRDX6 and Nerve
Skin Antibodies	>7 publications with PRDX6 and Skin