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BMP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9213323

The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage… More details

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Product Overview

Online Datasheet in PDF
Product Name
Bmp3, Polyclonal Antibody
Full Product Name
Bmp3 Antibody (N-term)
Product Gene Name
Product Synonym Names
Bone morphogenetic protein 3; BMP-3; Bone morphogenetic protein 3A; BMP-3A; Osteogenin; BMP3; BMP3A
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This Bmp3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human Bmp3.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Bmp3 peptide (MBS9222317) is used for blocking the activity of Bmp3 antibody (MBS9213323)
Molecular Weight
53372
Immunogen Sequence Positions
8-36
OMIM
112263
3D Structure
ModBase 3D Structure for P12645
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-BMP3 antibody

Applications Tested/Suitable for anti-BMP3 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BMP3 antibody
WB~~1:1000

Western Blot (WB) of anti-BMP3 antibody

Western blot analysis of hBmp3-E23 in 293 cell line lysates (35ug/lane). BMP3 (arrow) was detected using the purified Pab.
Rabbit Anti-BMP3 Polyclonal Antibody – Cat# MBS9213323

Western Blot (WB) of anti-BMP3 antibody

Western blot analysis of Bmp3 (arrow) using rabbit polyclonal Bmp3 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Bmp3 gene (Lane 2) (Origene Technologies).
Rabbit Anti-BMP3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9213323

Immunohistochemistry (IHC) of anti-BMP3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-BMP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9213323

Product References and Citations for anti-BMP3 antibody

Jin, Y., et al., Histol. Histopathol. 16(4):1013-1019 (2001).
Tabas, J.A., et al., Genomics 9(2):283-289 (1991).
Dickinson, M.E., et al., Genomics 6(3):505-520 (1990).
Wozney, J.M., et al., Science 242(4885):1528-1534 (1988).

Other Notes

Small volumes of anti-BMP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP3 purchase

MBS9213323 is an antibody targeting BMP3. Also known as Bmp3 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bone morphogenetic protein 3 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 3
NCBI Official Symbol
BMP3
NCBI Official Synonym Symbols
BMP-3A
UniProt Protein Name
Bone morphogenetic protein 3
UniProt Synonym Protein Names
Bone morphogenetic protein 3A; BMP-3A; Osteogenin
UniProt Gene Name
BMP3
UniProt Synonym Gene Names
BMP3A; BMP-3; BMP-3A
UniProt Entry Name
BMP3_HUMAN
NCBI Protein Information
bone morphogenetic protein 3

NCBI Summary for BMP3

BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP3

BMP3: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: regulation of apoptosis; ossification; cell-cell signaling; regulation of MAPKKK cascade; cartilage development; positive regulation of transcription from RNA polymerase II promoter; cell development; skeletal development; growth
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BMP3 antibody

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