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Adenylate Cyclase Type 10 (ADCY10) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1439058

This protein belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in… More details

$635 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adenylate cyclase type 10 (ADCY10), Recombinant Protein
Full Product Name
Recombinant Human Adenylate cyclase type 10 (ADCY10) , partial
Product Gene Name
ADCY10 recombinant protein
Product Synonym Gene Name
ADCY10
Sequence
TTGPVFCPRL YHLMAYVCIL MGDGQKCGLF LNTALRLSET QGNILEKCWL NMNKESWYST SELKEDQWLQ TILSLPSWEK IVAGRVNIQD LQKNKFLMRA NTVDNHF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
169,750 Da
Sequence Positions
1504-1610aa; Partial-length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
143870
3D Structure
ModBase 3D Structure for Q96PN6
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ADCY10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCY10 purchase

MBS1439058 is a recombinant protein targeting ADCY10. Also known as Recombinant Human Adenylate cyclase type 10 (ADCY10) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCY10. It may not necessarily be applicable to this product.

NCBI GI #
268370055
NCBI GeneID
55811
NCBI Accession #
NP_001161221.1
UniProt Primary Accession #
Q96PN6
UniProt Secondary Accession #
O95558; Q5R329; Q5R330; Q8WXV4; Q9NNX0; B4DZF0; F5GWS5
UniProt Related Accession #
Q96PN6
GenBank Nucleotide #
NM_001167749.2
NCBI Official Full Name
adenylate cyclase type 10 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 10
NCBI Official Symbol
ADCY10
NCBI Official Synonym Symbols
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
UniProt Protein Name
Adenylate cyclase type 10
UniProt Synonym Protein Names
AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY10
UniProt Synonym Gene Names
SAC; hsAC; sAC
NCBI Protein Information
adenylate cyclase type 10

NCBI Summary for ADCY10

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
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UniProt Comments for ADCY10

Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (). Involved in ciliary beat regulation (PubMed:17591988).
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Research Articles on ADCY10

1. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ADCY10 recombinant protein

 Reference Product  PubMed Publications
 PDE4B recombinant protein  >1 publications with ADCY10 and PDE4B
 PDE7A recombinant protein  >1 publications with ADCY10 and PDE7A
 PDE4A recombinant protein  >1 publications with ADCY10 and PDE4A

Pathways associated with ADCY10 recombinant protein

 Products by Pathway  Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 Hedgehog 'off' State Pathway antibodies  Hedgehog 'off' State Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hedgehog Pathway antibodies  Signaling By Hedgehog Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram

Diseases associated with ADCY10 recombinant protein

 Disease Name  Pubmed Publications
 Male Urogenital Diseases Antibodies  >5 publications with ADCY10 and Male Urogenital Diseases
 Hypertrophy Antibodies  >1 publications with ADCY10 and Hypertrophy

Organs/Tissues associated with ADCY10 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >5 publications with ADCY10 and Testis
 Eye Antibodies  >3 publications with ADCY10 and Eye
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