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FK506 Binding Protein 2 (FKBP2) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143984

Description: FKBP2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 122 amino acids (22-142 a.a.) and having a molecular mass of 13.4 kDa. The FKBP2 is purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FK506 Binding Protein 2 (FKBP2), Active Protein
Full Product Name
Recombinant Human FK506 Binding Protein 2
Product Gene Name
Product Synonym Names
FKBP2 Human; FK506 Binding Protein 2 Human Recombinant; FKBP13; FKBP-2; Peptidyl-prolyl cis-trans isomerase FKBP2; PPIase FKBP2; FK506-binding protein 2; Rotamase; Immunophilin FKBP13; 13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FKBP2; PPIase
Sequence
MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
Host
E Coli
Form/Format
The FKBP2 solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
Sterile Filtered clear colorless solution.
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
15,649 Da
OMIM
186946
3D Structure
ModBase 3D Structure for P26885
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Specific activity is > 270 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Product Categories/Family for FKBP2 active protein

Other Notes

Small volumes of FKBP2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP2 purchase

MBS143984 is an active protein targeting FKBP2. Also known as Recombinant Human FK506 Binding Protein 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase FKBP2
NCBI Official Synonym Full Names
FK506 binding protein 2, 13kDa
NCBI Official Symbol
FKBP2
NCBI Official Synonym Symbols
PPIase; FKBP-13
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP2
UniProt Synonym Protein Names
13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FK506-binding protein 2; FKBP-2; Immunophilin FKBP13; Rotamase
Protein Family
UniProt Gene Name
FKBP2
UniProt Synonym Gene Names
FKBP13; PPIase FKBP2; 13 kDa FKBP; FKBP-13; FKBP-2
UniProt Entry Name
FKBP2_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP2; 13 kDa FK506-binding protein; 13 kDa FKBP; FK506-binding protein 2 (13kD); FKBP-2; PPIase FKBP2; immunophilin FKBP13; proline isomerase; rapamycin-binding protein; rotamase

NCBI Summary for FKBP2

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
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UniProt Comments for FKBP2

FKBP2: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Protein type: Endoplasmic reticulum; Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 11q13.1-q13.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity

Biological Process: protein peptidyl-prolyl isomerization
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP2 active protein

Diseases associated with FKBP2 active protein

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >1 publications with FKBP2 and Hyperplasia
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