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Nudix Type Motif 5 (NUDT5) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144026

Description: NUDT5 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 239 amino acids (1-219 a.a.) and having a molecular mass of 26.5 kDa. The NUDT5 is fused to a 20 amino acid His-Tag at N-terminus and purified… More details

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Product Overview

Online Datasheet in PDF
Product Name
Nudix Type Motif 5 (NUDT5), Recombinant Protein
Full Product Name
Recombinant Human Nudix Type Motif 5
Product Gene Name
NUDT5 recombinant protein
Product Synonym Names
NUDT5 Human; Nudix Type Motif 5 Human Recombinant; hYSAH1; YSA1; YSA1H; ADP-sugar pyrophosphatase; EC=3.6.1.-; EC=3.6.1.13; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; HSPC115
Sequence
MGSSHHH HHH SSGLVPRGSH MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF
Host
E Coli
Form/Format
NUDT5 Human 1mg/ml solution containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
NUDT5 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Molecular Weight
24,328 Da
OMIM
609230
3D Structure
ModBase 3D Structure for Q9UKK9

Product Categories/Family for NUDT5 recombinant protein

Enzymes; Nudix Type Motif

Other Notes

Small volumes of NUDT5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NUDT5 purchase

MBS144026 is a recombinant protein targeting NUDT5. Also known as Recombinant Human Nudix Type Motif 5. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NUDT5. It may not necessarily be applicable to this product.

NCBI GI #
37594464
NCBI GeneID
11164
NCBI Accession #
NP_054861.2
UniProt Primary Accession #
Q9UKK9
UniProt Secondary Accession #
Q6IAG0; Q9UH49; A8K516
UniProt Related Accession #
Q9UKK9
GenBank Nucleotide #
NM_014142.2
NCBI Official Full Name
ADP-sugar pyrophosphatase
NCBI Official Synonym Full Names
nudix (nucleoside diphosphate linked moiety X)-type motif 5
NCBI Official Symbol
NUDT5
NCBI Official Synonym Symbols
YSA1; YSA1H; YSAH1; hYSAH1
UniProt Protein Name
ADP-sugar pyrophosphatase
UniProt Synonym Protein Names
8-oxo-dGDP phosphatase (EC:3.6.1.58); Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; YSA1H
Protein Family
ADP-sugar pyrophosphatase
UniProt Gene Name
NUDT5
UniProt Synonym Gene Names
Nudix motif 5
UniProt Entry Name
NUDT5_HUMAN
NCBI Protein Information
ADP-sugar pyrophosphatase; 8-oxo-dGDP phosphatase

NCBI Summary for NUDT5

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
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UniProt Comments for NUDT5

NUDT5: Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Belongs to the Nudix hydrolase family.

Protein type: EC 3.6.1.13; Nucleotide Metabolism - purine; Phosphatase; EC 3.6.1.58

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: intracellular; cytosol; nucleus

Molecular Function: snoRNA binding; m7G(5')pppN diphosphatase activity; ADP-ribose diphosphatase activity; nucleoside-diphosphatase activity; magnesium ion binding; ADP-sugar diphosphatase activity

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleotide metabolic process; D-ribose catabolic process; ribonucleoside diphosphate catabolic process
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Research Articles on NUDT5

1. The NUDT5 protein could play significant roles in the prevention of RNA oxidation and survival in human fibroblast cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NUDT5 recombinant protein

 Reference Product  PubMed Publications
 NUDT9 recombinant protein  >2 publications with NUDT5 and NUDT9

Pathways associated with NUDT5 recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Phosphate Bond Hydrolysis By NUDT Proteins Pathway antibodies  Phosphate Bond Hydrolysis By NUDT Proteins Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with NUDT5 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with NUDT5 and Necrosis

Organs/Tissues associated with NUDT5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with NUDT5 and Liver
 Lung Antibodies  >1 publications with NUDT5 and Lung
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