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Tryptophan 2,3-Dioxygenase (TDO2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144468

Description: TDO2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 426 amino acids (1-406 a.a.) and having a molecular mass of 50kDa. The TDO2 is purified by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tryptophan 2,3-Dioxygenase (TDO2), Recombinant Protein
Full Product Name
Recombinant Human Tryptophan 2,3-Dioxygenase
Product Gene Name
Product Synonym Names
TDO2 Human; Tryptophan 2,3-Dioxygenase Human Recombinant; Tryptophan 2; 3-dioxygenase; TDO; Tryptamin 2; 3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; TDO2; TPH2
Sequence
MGSSHHH HHH SSGLVPRGSH MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK VLNAQELQSE TKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVSRMHRVSV ILKLLVQQFS ILETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQN MRVPYNRRHY RDNFKGEENE LLLKSEQEKT LLELVEAWLE RTPGLEPHGF NFWGKLEKNI TRGLEEEFIR IQAKEESEEK EEQVAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYRALQ GALMIYFYRE EPRFQVPFQL LTSLMDIDSL MTKWRYNHVC MVHRMLGSKA GTGGSSGYHY LRSTVSDRYK VFVDLFNLST YLIPRHWIPK MNPTIHKFLY TAEYCDSSYF SSDESD
Host
E Coli
Form/Format
The TDO2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
47,872 Da
OMIM
191070
3D Structure
ModBase 3D Structure for P48775

Product Categories/Family for TDO2 recombinant protein

Other Notes

Small volumes of TDO2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TDO2 purchase

MBS144468 is a recombinant protein targeting TDO2. Also known as Recombinant Human Tryptophan 2,3-Dioxygenase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TDO2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tryptophan 2,3-dioxygenase
NCBI Official Synonym Full Names
tryptophan 2,3-dioxygenase
NCBI Official Symbol
TDO2
NCBI Official Synonym Symbols
TO; TDO; TPH2; TRPO
UniProt Protein Name
Tryptophan 2,3-dioxygenase
UniProt Synonym Protein Names
Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase
UniProt Gene Name
TDO2
UniProt Entry Name
T23O_HUMAN
NCBI Protein Information
tryptophan 2,3-dioxygenase; TDO; TDO2; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophanase

NCBI Summary for TDO2

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
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UniProt Comments for TDO2

TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.

Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.11; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytosol

Molecular Function: amino acid binding; metal ion binding; heme binding; oxygen binding; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; tryptophan catabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TDO2 recombinant protein

 Reference Product  PubMed Publications
 IDO1 recombinant protein  >7 publications with TDO2 and IDO1
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