Human APIP Recombinant Protein – Cat# MBS1445779

Probable Methylthioribulose-1-Phosphate Dehydratase (APIP) Human Recombinant Protein

Name: APIP Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1445779
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1445779

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and… More details

$335 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Probable methylthioribulose-1-phosphate dehydratase (APIP), Recombinant Protein

Full Product Name

Recombinant Human Probable methylthioribulose-1-phosphate dehydratase (APIP)

Product Gene Name

APIP recombinant protein

Product Synonym Gene Name

APIP; CGI-29

Product Synonym Names

Probable methylthioribulose-1-phosphate dehydratase; MTRu-1-P dehydratase; EC=4.2.1.109; APAF1-interacting protein

Sequence

MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP SGVQKERIQP EDMFVCDINE KDISGPSPSK KLKKSQCTPL FMNAYTMRGA GAVIHTHSKA AVMATLLFPG REFKITHQEM IKGIKKCTSG GYYRYDDMLV VPIIENTPEE KDLKDRMAHA MNEYPDSCAV LVRRHGVYVW GETWEKAKTM CECYDYLFDI AVSMKKVGLD PSQLPVGENG IV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

54.1 kDa

Sequence Positions

1-242aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

612491

3D Structure

ModBase 3D Structure for Q96GX9

Species

Homo sapiens (Human)

Product Categories/Family for APIP recombinant protein

Cell Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of APIP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APIP purchase

MBS1445779 is a recombinant protein targeting APIP. Also known as Recombinant Human Probable methylthioribulose-1-phosphate dehydratase (APIP). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for APIP. It may not necessarily be applicable to this product.

NCBI GI #

166235186

NCBI GeneID

51074

NCBI Accession #

NP_057041.2

UniProt Primary Accession #

Q96GX9

UniProt Secondary Accession #

Q6PJX6; Q8WVU2; Q96HK2; Q9Y318; A8K9D3

UniProt Related Accession #

Q96GX9

GenBank Nucleotide #

NM_015957.3

NCBI Official Full Name

methylthioribulose-1-phosphate dehydratase

NCBI Official Synonym Full Names

APAF1 interacting protein

NCBI Official Symbol

APIP

NCBI Official Synonym Symbols

APIP2; CGI29; hAPIP; CGI-29; MMRP19

UniProt Protein Name

Methylthioribulose-1-phosphate dehydratase

UniProt Synonym Protein Names

APAF1-interacting protein

UniProt Gene Name

APIP

UniProt Synonym Gene Names

MTRu-1-P dehydratase

UniProt Entry Name

MTNB_HUMAN

NCBI Protein Information

methylthioribulose-1-phosphate dehydratase; MTRu-1-P dehydratase; APAF1-interacting protein; probable methylthioribulose-1-phosphate dehydratase

NCBI Summary for APIP

APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

UniProt Comments for APIP

MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Amino Acid Metabolism - cysteine and methionine; EC 4.2.1.109

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm

Molecular Function: identical protein binding; 5-methylthioribulose-1-phosphate 4-dehydratase activity; protein binding; zinc ion binding

Biological Process: methionine salvage; sulfur amino acid metabolic process; apoptosis; methionine biosynthetic process from S-adenosylmethionine; negative regulation of apoptosis; polyamine metabolic process

Research Articles on APIP

1. APIP/MtnB functions as a cell death inhibitor independently of its MtnB enzyme activity for apoptosis induced by either hypoxia or etoposide, but dependently for caspase-1-induced pyroptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APIP recombinant protein

Reference Product	PubMed Publications
CASP9 recombinant protein	>6 publications with APIP and CASP9
APAF1 recombinant protein	>5 publications with APIP and APAF1
MTAP recombinant protein	>1 publications with APIP and MTAP

Pathways associated with APIP recombinant protein

Products by Pathway	Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Metabolism Of Polyamines Pathway antibodies	Metabolism Of Polyamines Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation I Pathway antibodies	S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation I Pathway Diagram
Sulfur Amino Acid Metabolism Pathway antibodies	Sulfur Amino Acid Metabolism Pathway Diagram

Diseases associated with APIP recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with APIP and Neoplasms
Liver Diseases Antibodies	>1 publications with APIP and Liver Diseases
Inflammation Antibodies	>1 publications with APIP and Inflammation
Liver Neoplasms Antibodies	>1 publications with APIP and Liver Neoplasms

Organs/Tissues associated with APIP recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>3 publications with APIP and Lung
Bone Antibodies	>1 publications with APIP and Bone
Heart Antibodies	>1 publications with APIP and Heart
Thymus Antibodies	>1 publications with APIP and Thymus
Prostate Antibodies	>1 publications with APIP and Prostate
Liver Antibodies	>1 publications with APIP and Liver
Muscle Antibodies	>1 publications with APIP and Muscle
Kidney Antibodies	>1 publications with APIP and Kidney
Bone Marrow Antibodies	>1 publications with APIP and Bone Marrow
Brain Antibodies	>1 publications with APIP and Brain