Macrophage Migration Inhibitor Factor (rMIF) Rat Recombinant Protein

MIF: a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase.

Protein type: Amino Acid Metabolism - tyrosine; EC 5.3.2.1; Isomerase; Apoptosis; Amino Acid Metabolism - phenylalanine; EC 5.3.3.12; Cytokine; Cell development/differentiation

Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region; intracellular; nucleus; myelin sheath; vesicle

Molecular Function: phenylpyruvate tautomerase activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein complex binding; cytokine activity; dopachrome isomerase activity; chemoattractant activity; receptor binding

Biological Process: skin development; positive regulation of immune response; wound healing; DNA damage response, signal transduction by p53 class mediator; metabolic process; response to menaquinone; positive regulation of potassium ion transport; response to glucocorticoid stimulus; drinking behavior; response to hormone stimulus; positive regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of cellular protein metabolic process; response to lipopolysaccharide; positive regulation of smooth muscle cell migration; prostaglandin biosynthetic process; response to estradiol stimulus; response to insulin stimulus; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of glucose import; positive regulation of MAP kinase activity; negative regulation of myeloid cell apoptosis; response to vitamin E; positive regulation of fibroblast proliferation; cell surface receptor linked signal transduction; negative regulation of mature B cell apoptosis; positive chemotaxis; hair follicle development; positive regulation of acute inflammatory response; positive regulation of B cell proliferation; inflammatory response; aging; response to drug; positive regulation of axon regeneration; response to inorganic substance; carboxylic acid metabolic process; cell aging; positive regulation of peptidyl-serine phosphorylation; brain renin-angiotensin system; regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; response to heat; response to mechanical stimulus; positive regulation of glycolysis; innate immune response; spermatogenesis; brain development; positive regulation of protein amino acid phosphorylation; response to progesterone stimulus; positive regulation of phosphorylation; positive regulation of cytokine secretion; negative regulation of apoptosis