Human IL36A Active Protein – Cat# MBS145024

Interleukin-36 Alpha (IL36A) Human Active Protein

Name: IL36A Active Protein; Interleukin-36 Alpha; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145024
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145024

Description: IL36A 158 a.a. Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 17.7kDa.The IL36A 158 a.a. Human is purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-36 Alpha (IL36A), Active Protein

Full Product Name

Recombinant Human Interleukin-36 Alpha 158 a.a.

Product Gene Name

IL36A active protein

Product Synonym Names

IL36A 158 a.a. Human; Interleukin-36 Alpha 158 a.a. Human Recombinant; Interleukin 36 alpha; FIL1E; IL1F6; FIL1; IL1(EPSILON); interleukin 1 family member 6 (epsilon); MGC129552; MGC129553; IL36A 158 a.a.

Sequence

MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

Host

E Coli

Form/Format

Lyophilized from a 0.2?m filtered concentrated solution in 2xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE and HPLC analyses.

Molecular Weight

17,684 Da

OMIM

605509

3D Structure

ModBase 3D Structure for Q9UHA7

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IL36A 158 a.a. Human in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Fully biologically active when compared to standard. The specific activity determined by its ability in a functional ELISA. Immobilized rHuIL-36? at 1 ?g/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5?g/ml corresponding to a specific activity of 200,000-6,666,667IU/mg.

Product Categories/Family for IL36A active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of IL36A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL36A purchase

MBS145024 is an active protein targeting IL36A. Also known as Recombinant Human Interleukin-36 Alpha 158 a.a.. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL36A. It may not necessarily be applicable to this product.

NCBI GI #

7657092

NCBI GeneID

27179

NCBI Accession #

NP_055255.1

UniProt Primary Accession #

Q9UHA7

UniProt Secondary Accession #

Q53SR7; Q5BLR4; Q7RTZ8; B2RAD9

UniProt Related Accession #

Q9UHA7

GenBank Nucleotide #

NM_014440.1

NCBI Official Full Name

interleukin-36 alpha

NCBI Official Synonym Full Names

interleukin 36, alpha

NCBI Official Symbol

IL36A

NCBI Official Synonym Symbols

FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)

UniProt Protein Name

Interleukin-36 alpha

UniProt Synonym Protein Names

FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6

Protein Family

Interleukin

UniProt Gene Name

IL36A

UniProt Synonym Gene Names

FIL1E; IL1E; IL1F6; IL-1 epsilon; IL-1F6

UniProt Entry Name

IL36A_HUMAN

NCBI Protein Information

interleukin-36 alpha; FIL1 epsilon; IL-1 epsilon; IL-1F6 (FIL-1-epsilon); interleukin 1 family, member 6 (epsilon); interleukin 1, epsilon; interleukin-1 epsilon; interleukin-1 family member 6

UniProt Comments for IL36A

IL1F6: Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-1 receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-6 production; innate immune response; immune response; inflammatory response

Research Articles on IL36A

1. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with IL36A active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>1 publications with IL36A and Immune System Diseases
Necrosis Antibodies	>1 publications with IL36A and Necrosis
Carcinoma, Hepatocellular Antibodies	>1 publications with IL36A and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with IL36A and Liver Neoplasms