Human AS3MT Recombinant Protein – Cat# MBS145238

Arsenic Methyltransferase (AS3MT) Human Recombinant Protein

Name: AS3MT Recombinant Protein; Arsenic Methyltransferase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145238
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145238

Description: AS3MT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 399 amino acids (1-375 a.a.) and having a molecular mass of 44.3kDa.AS3MT is fused to a 24 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Arsenic Methyltransferase (AS3MT), Recombinant Protein

Full Product Name

Recombinant Human Arsenic Methyltransferase

Product Gene Name

AS3MT recombinant protein

Product Synonym Names

AS3MT Human; Arsenic Methyltransferase Human Recombinant; Arsenite methyltransferase; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; AS3MT; CYT19; RP11-753C18.6

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMA ALRD AEIQKDVQTY YGQVLKRSAD LQTNGCVTTA RPVPKHIREA LQNVHEEVAL RYYGCGLVIP EHLENCWILD LGSGSGRDCY VLSQLVGEKG HVTGIDMTKG QVEVAEKYLD YHMEKYGFQA SNVTFIHGYI EKLGEAGIKN ESHDIVVSNC VINLVPDKQQ VLQEAYRVLK HGGELYFSDV YTSLELPEEI RTHKVLWGEC LGGALYWKEL AVLAQKIGFC PPRLVTANLI TIQNKELERV IGDCRFVSAT FRLFKHSKTG PTKRCQVIYN GGITGHEKEL MFDANFTFKE GEIVEVDEET AAILKNSRFA QDFLIRPIGE KLPTSGGCSA LELKDIITDP FKLAEESDSM KSRCVPDAAG GCCGTKKSC.

Host

E Coli

Form/Format

AS3MT protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.15M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Molecular Weight

31,098 Da

OMIM

611806

3D Structure

ModBase 3D Structure for Q9HBK9

Product Categories/Family for AS3MT recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of AS3MT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AS3MT purchase

MBS145238 is a recombinant protein targeting AS3MT. Also known as Recombinant Human Arsenic Methyltransferase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AS3MT. It may not necessarily be applicable to this product.

NCBI GI #

109389364

NCBI GeneID

57412

NCBI Accession #

NP_065733.2

UniProt Primary Accession #

Q9HBK9

UniProt Secondary Accession #

Q0VDK3; Q0VDK4; Q5PZ02; A6NP79

UniProt Related Accession #

Q9HBK9

GenBank Nucleotide #

NM_020682.3

NCBI Official Full Name

arsenite methyltransferase

NCBI Official Synonym Full Names

arsenite methyltransferase

NCBI Official Symbol

AS3MT

NCBI Official Synonym Symbols

CYT19

UniProt Protein Name

Arsenite methyltransferase

UniProt Synonym Protein Names

Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase

Protein Family

Arsenite methyltransferase

UniProt Gene Name

AS3MT

UniProt Synonym Gene Names

CYT19

UniProt Entry Name

AS3MT_HUMAN

NCBI Protein Information

arsenite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; methylarsonite methyltransferase; methyltransferase cyt19

NCBI Summary for AS3MT

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

UniProt Comments for AS3MT

AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.

Protein type: Methyltransferase; Mitochondrial; EC 2.1.1.137

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process

Research Articles on AS3MT

1. Two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AS3MT recombinant protein

Reference Product	PubMed Publications
GSTO1 recombinant protein	>16 publications with AS3MT and GSTO1
GSTO2 recombinant protein	>8 publications with AS3MT and GSTO2
CNNM2 recombinant protein	>3 publications with AS3MT and CNNM2
C10orf32 recombinant protein	>1 publications with AS3MT and C10orf32

Pathways associated with AS3MT recombinant protein

Products by Pathway	Pathway Diagram
Arsenate Detoxification I (glutaredoxin) Pathway antibodies	Arsenate Detoxification I (glutaredoxin) Pathway Diagram
Arsenate Detoxification I (glutaredoxin) Pathway antibodies	Arsenate Detoxification I (glutaredoxin) Pathway Diagram

Diseases associated with AS3MT recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>22 publications with AS3MT and Nervous System Diseases
Neurotoxicity Syndromes Antibodies	>20 publications with AS3MT and Neurotoxicity Syndromes
Arsenic Poisoning Antibodies	>20 publications with AS3MT and Arsenic Poisoning
Poisoning Antibodies	>20 publications with AS3MT and Poisoning
Cardiovascular Diseases Antibodies	>5 publications with AS3MT and Cardiovascular Diseases
Hyperplasia Antibodies	>4 publications with AS3MT and Hyperplasia
Disease Models, Animal Antibodies	>3 publications with AS3MT and Disease Models, Animal
Atherosclerosis Antibodies	>3 publications with AS3MT and Atherosclerosis
Urinary Bladder Neoplasms Antibodies	>3 publications with AS3MT and Urinary Bladder Neoplasms
Vascular Diseases Antibodies	>2 publications with AS3MT and Vascular Diseases

Organs/Tissues associated with AS3MT recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>8 publications with AS3MT and Skin
Lung Antibodies	>4 publications with AS3MT and Lung
Kidney Antibodies	>4 publications with AS3MT and Kidney
Brain Antibodies	>3 publications with AS3MT and Brain
Prostate Antibodies	>2 publications with AS3MT and Prostate
Muscle Antibodies	>1 publications with AS3MT and Muscle
Vascular Antibodies	>1 publications with AS3MT and Vascular
Embryonic Tissue Antibodies	>1 publications with AS3MT and Embryonic Tissue