MDS1 and EVI1 Complex Locus (MECOM) Human Recombinant Protein

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

EVI1: a zinc finger transcriptional regulator that binds to DNA sequences in the promoter region of target genes and positively or negatively regulates their expression. An oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. Originally identified as a common site of viral integration in murine myeloid leukemia. Involved in human myeloid disorders through chromosome translocation and inversion and is also implicated in solid tumor formation. At least six isoforms of the human protein are formed due to alternative usage of 5'-ends, alternative splicing, and intergenic splicing which results in the formation of a fusion protein with MDS1, which can be expressed in normal tissues.

Protein type: Transcription, coactivator/corepressor; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; histone deacetylase complex; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; metal ion binding; transcription factor activity

Biological Process: embryonic forelimb morphogenesis; negative regulation of JNK cascade; pericardium development; transcription, DNA-dependent; regulation of cell cycle; apoptosis; in utero embryonic development; positive regulation of transcription, DNA-dependent; neutrophil homeostasis; embryonic hindlimb morphogenesis; regulation of cell proliferation; post-embryonic development; response to bacterium; regulation of transcription, DNA-dependent; forebrain development; negative regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; inflammatory response; negative regulation of transcription, DNA-dependent