Human OSM Active Protein – Cat# MBS145599

Oncostatin-M (OSM) Human Active Protein

Name: OSM Active Protein; Oncostatin-M; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145599
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145599

Description: Oncostatin-M Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids and having a molecular mass of 22kDa. The OSM is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Oncostatin-M (OSM), Active Protein

Full Product Name

Recombinant Human Oncostatin-M (195 a.a.)

Product Gene Name

OSM active protein

Product Synonym Names

OSM Human, 195 a.a; Oncostatin-M Human Recombinant (195 a.a.); OSM; MGC20461; Oncostatin M; OSM (195 a.a.)

Sequence

AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSR

Host

E Coli

Form/Format

Lyophilized from a concentrated (1mg/ml) solution containing 1xPBS pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Oncostatin M although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Oncostatin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

28,484 Da

OMIM

165095

3D Structure

ModBase 3D Structure for P13725

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Oncostatin M in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 0.2ng/ml, corresponding to a specific activity of > 5.0x106 units/mg.

Product Categories/Family for OSM active protein

Cytokines and Growth Factors; Growth Factors; Oncostatin-M

Other Notes

Small volumes of OSM active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSM purchase

MBS145599 is an active protein targeting OSM. Also known as Recombinant Human Oncostatin-M (195 a.a.). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.

NCBI GI #

10092621

NCBI GeneID

5008

NCBI Accession #

NP_065391.1

UniProt Primary Accession #

P13725

UniProt Secondary Accession #

Q6FHP8; Q9UCP6

UniProt Related Accession #

P13725

GenBank Nucleotide #

NM_020530.4

NCBI Official Full Name

oncostatin-M preproprotein

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

OSM

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin

UniProt Gene Name

OSM

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_HUMAN

NCBI Protein Information

oncostatin-M

NCBI Summary for OSM

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for OSM

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; positive regulation of acute inflammatory response; regulation of growth; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of meiosis; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response

Research Articles on OSM

1. oncostatin M is a cytokine possessing vigorous antiviral and immunostimulatory properties which is released by APC upon interaction with CD40L present on activated CD4+ T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with OSM active protein

Reference Product	PubMed Publications
LIFR active protein	>393 publications with OSM and LIFR
STAT3 active protein	>252 publications with OSM and STAT3
IL6ST active protein	>178 publications with OSM and IL6ST
STAT1 active protein	>82 publications with OSM and STAT1
OSMR active protein	>69 publications with OSM and OSMR
SOCS3 active protein	>30 publications with OSM and SOCS3
IL3 active protein	>2 publications with OSM and IL3
MMP1 active protein	>2 publications with OSM and MMP1

Pathways associated with OSM active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with OSM active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>213 publications with OSM and Inflammation
Necrosis Antibodies	>152 publications with OSM and Necrosis
Liver Diseases Antibodies	>74 publications with OSM and Liver Diseases
Disease Models, Animal Antibodies	>70 publications with OSM and Disease Models, Animal
Kidney Diseases Antibodies	>54 publications with OSM and Kidney Diseases
Fibrosis Antibodies	>48 publications with OSM and Fibrosis
Breast Neoplasms Antibodies	>45 publications with OSM and Breast Neoplasms
Lung Diseases Antibodies	>38 publications with OSM and Lung Diseases
Neoplasms, Experimental Antibodies	>30 publications with OSM and Neoplasms, Experimental
Lung Neoplasms Antibodies	>25 publications with OSM and Lung Neoplasms

Organs/Tissues associated with OSM active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>462 publications with OSM and Blood
Kidney Antibodies	>127 publications with OSM and Kidney
Lung Antibodies	>99 publications with OSM and Lung
Intestine Antibodies	>22 publications with OSM and Intestine
Thymus Antibodies	>17 publications with OSM and Thymus
Ovary Antibodies	>15 publications with OSM and Ovary
Uncharacterized Tissue Antibodies	>2 publications with OSM and Uncharacterized Tissue