PIN1 cDNA Clone – Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1 (Human)

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

PIN1: a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2-M transition of the cell cycle. Has two distinct functional domains: an N-terminal WW domain and a C-terminal PPlase domain. Pin1 interacts with a series of mitotic phosphoproteins, including Plk1, cdc25C and cdc27, catalyzing pSer-Pro or pThr/Pro cis/trans isomerizations. Displays a preference for an acidic residue n-terminal to the isomerized proline bond.

Protein type: EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cytosol; midbody; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; GTPase activating protein binding; mitogen-activated protein kinase kinase binding; motor activity; peptidyl-prolyl cis-trans isomerase activity; phosphoserine binding; phosphothreonine binding; protein binding

Biological Process: negative regulation of interferon type I production; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; neuron differentiation; positive regulation of GTPase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ubiquitin-protein ligase activity; protein peptidyl-prolyl isomerization; protein stabilization; regulation of cytokinesis; regulation of mitosis; synapse organization and biogenesis