Human FNDC5 Active Protein – Cat# MBS145713

Fibronectin Type III Domain Containing 5 (FNDC5) Human Active Protein

Name: FNDC5 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145713
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145713

Description: Fibronectin Type III Domain Containing 5 Human Recombinant produced in yeast is a glycosylated, polypeptide chain containing 110 amino acids and having a molecular mass of 20-25 kDa.FNDC5 is purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fibronectin Type III Domain Containing 5 (FNDC5), Active Protein

Full Product Name

Recombinant Human Fibronectin Type III Domain Containing 5, Yeast

Product Gene Name

FNDC5 active protein

Product Synonym Names

FNDC5 Human, Yeast; Fibronectin Type III Domain Containing 5 Human Recombinant, Yeast; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FRCP2; FNDC5; FNDC5 Yeast

Sequence

S_P__S__A_ _P__V__N__ V__T__V__R __H__L__K_ _A__N__S__ A__V__V__S _W__D__V__ L__E__D__E __V__V__I_ _G__F__A__ I__S__Q__Q __K__K__D _V__R__M__ L__R__F__I __Q__E__V_ _N__T__T__ T__R__S__C __A__L__W_ _ D__L__E__E __D__T__E_ _Y__I__V__ H__V__Q__A __I__S__I_ _Q__G__Q_S __P__A__S_ _E__P__V__ L__F__K__T __P__R__E_ _A__E__K__ M__A__S_ K__N__K__D __E__V__T_ _M__K__E

Form/Format

The FNDC5 was lyophilized from 0.45 um filtered solution in PBS.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized Fibronectin Type III Domain Containing 5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FNDC5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

15,527 Da

OMIM

611906

3D Structure

ModBase 3D Structure for Q8NAU1

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Fibronectin Type III Domain Containing 5 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The biological activity of recombinant human irisin was measured by the ability to induce UCP-1 expression of adipocytes. The specific activity is 10ng/ml.

Product Categories/Family for FNDC5 active protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of FNDC5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FNDC5 purchase

MBS145713 is an active protein targeting FNDC5. Also known as Recombinant Human Fibronectin Type III Domain Containing 5, Yeast.

Additional Details

NCBI/Uniprot data below describe general gene information for FNDC5. It may not necessarily be applicable to this product.

NCBI GI #

511093995

NCBI GeneID

252995

NCBI Accession #

NP_001165411.2

UniProt Primary Accession #

Q8NAU1

UniProt Secondary Accession #

Q6P6D9; Q7Z676; A6NMC9; D3DPQ6

UniProt Related Accession #

Q8NAU1

GenBank Nucleotide #

NM_001171940.1

NCBI Official Full Name

fibronectin type III domain-containing protein 5 isoform 3 preproprotein

NCBI Official Synonym Full Names

fibronectin type III domain containing 5

NCBI Official Symbol

FNDC5

NCBI Official Synonym Symbols

FRCP2; irisin

UniProt Protein Name

Fibronectin type III domain-containing protein 5

UniProt Synonym Protein Names

Fibronectin type III repeat-containing protein 2Irisin

Protein Family

Fibronectin type III domain-containing protein

UniProt Gene Name

FNDC5

UniProt Synonym Gene Names

FRCP2

UniProt Entry Name

FNDC5_HUMAN

NCBI Protein Information

fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2

NCBI Summary for FNDC5

This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

UniProt Comments for FNDC5

FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: peroxisomal membrane; endoplasmic reticulum; integral to membrane; plasma membrane; extracellular region

Molecular Function: hormone activity

Biological Process: response to muscle activity

Research Articles on FNDC5

1. Irisin suppresses NFKB activation, an opposite effect of other myokines such as tumor necrosis factor alpha.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with FNDC5 active protein

Disease Name	Pubmed Publications
Weight Loss Antibodies	>7 publications with FNDC5 and Weight Loss
Fatty Liver Antibodies	>7 publications with FNDC5 and Fatty Liver
Kidney Diseases Antibodies	>5 publications with FNDC5 and Kidney Diseases
Inflammation Antibodies	>5 publications with FNDC5 and Inflammation
Necrosis Antibodies	>5 publications with FNDC5 and Necrosis
Liver Diseases Antibodies	>4 publications with FNDC5 and Liver Diseases
Weight Gain Antibodies	>2 publications with FNDC5 and Weight Gain
Rhabdomyosarcoma Antibodies	>2 publications with FNDC5 and Rhabdomyosarcoma
Nervous System Diseases Antibodies	>1 publications with FNDC5 and Nervous System Diseases
Breast Neoplasms Antibodies	>1 publications with FNDC5 and Breast Neoplasms

Organs/Tissues associated with FNDC5 active protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>78 publications with FNDC5 and Muscle
Blood Antibodies	>61 publications with FNDC5 and Blood
Heart Antibodies	>17 publications with FNDC5 and Heart
Brain Antibodies	>12 publications with FNDC5 and Brain
Kidney Antibodies	>8 publications with FNDC5 and Kidney
Vascular Antibodies	>4 publications with FNDC5 and Vascular
Embryonic Tissue Antibodies	>4 publications with FNDC5 and Embryonic Tissue
Lung Antibodies	>2 publications with FNDC5 and Lung
Mammary Gland Antibodies	>1 publications with FNDC5 and Mammary Gland
Ovary Antibodies	>1 publications with FNDC5 and Ovary